IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v445y2007i7130d10.1038_nature05658.html
   My bibliography  Save this article

Can osteoclasts be excluded? (Reply)

Author

Listed:
  • D. Holstead Jones

    (*Faculty of Health Sciences, University of Ontario Institute of Technology, Oshawa, Ontario L1H 7K4, Canada
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences
    University of Toronto
    University of Toronto)

  • Tomoki Nakashima

    (Institute of Molecular Biotechnology of the Austrian Academy of Sciences)

  • Otto H. Sanchez

    (Ontario Cancer Institute, University Health Network)

  • Ivona Kozieradzki

    (Institute of Molecular Biotechnology of the Austrian Academy of Sciences
    University of Toronto
    University of Toronto)

  • Svetlana V. Komarova

    (‖Faculty of Dentistry, McGill University, Montreal, Quebec H3A 1A4, Canada)

  • Ildiko Sarosi

    (Amgen Inc., Thousand Oaks)

  • Sean Morony

    (Amgen Inc., Thousand Oaks)

  • Evelyn Rubin

    (University of Toronto
    University of Toronto)

  • Renu Sarao

    (Institute of Molecular Biotechnology of the Austrian Academy of Sciences)

  • Carlo V. Hojilla

    (Ontario Cancer Institute, University Health Network)

  • Vukoslav Komnenovic

    (Institute of Molecular Biotechnology of the Austrian Academy of Sciences)

  • Young-Yun Kong

    (Pohang University of Science and Technology, Pohang)

  • Martin Schreiber

    (Medical University of Vienna, Waehringer Guertel 18-20)

  • S. Jeffrey Dixon

    (CIHR Group in Skeletal Development and Remodeling, Schulich School of Medicine & Dentistry, The University of Western Ontario)

  • Stephen M. Sims

    (CIHR Group in Skeletal Development and Remodeling, Schulich School of Medicine & Dentistry, The University of Western Ontario)

  • Rama Khokha

    (University of Toronto
    ‖Faculty of Dentistry, McGill University, Montreal, Quebec H3A 1A4, Canada)

  • Teiji Wada

    (Institute of Molecular Biotechnology of the Austrian Academy of Sciences)

  • Josef M. Penninger

    (Institute of Molecular Biotechnology of the Austrian Academy of Sciences
    University of Toronto
    University of Toronto)

Abstract

Martin and Mundy 1 emphasize the crucial role played by osteoclasts in the metastasis of many tumour types to bone. Our intention was not to question the importance of osteoclasts in bone metastases, but rather to show that RANK ligand (RANKL) exerts additional action on cancer cells beyond its effects on osteoclasts2. We reported that epithelial tumour cells can express RANK, a finding that is supported by earlier work3; that RANKL has chemotactic activity4; and that in vivo inhibition of RANKL by osteoprotegerin reduces tumour burden in bone when assessed in a previously published experimental system5.

Suggested Citation

  • D. Holstead Jones & Tomoki Nakashima & Otto H. Sanchez & Ivona Kozieradzki & Svetlana V. Komarova & Ildiko Sarosi & Sean Morony & Evelyn Rubin & Renu Sarao & Carlo V. Hojilla & Vukoslav Komnenovic & Y, 2007. "Can osteoclasts be excluded? (Reply)," Nature, Nature, vol. 445(7130), pages 19-20, February.
    • Handle: RePEc:nat:nature:v:445:y:2007:i:7130:d:10.1038_nature05658
    DOI: 10.1038/nature05658
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature05658
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature05658?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:445:y:2007:i:7130:d:10.1038_nature05658. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.