IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v445y2007i7128d10.1038_nature05515.html
   My bibliography  Save this article

Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation

Author

Listed:
  • Guillermo Barreto

    (German Cancer Research Center)

  • Andrea Schäfer

    (German Cancer Research Center)

  • Joachim Marhold

    (German Cancer Research Center)

  • Dirk Stach

    (German Cancer Research Center)

  • Suresh K. Swaminathan

    (German Cancer Research Center)

  • Vikas Handa

    (German Cancer Research Center)

  • Gabi Döderlein

    (German Cancer Research Center)

  • Nicole Maltry

    (German Cancer Research Center)

  • Wei Wu

    (German Cancer Research Center
    Tsinghua University)

  • Frank Lyko

    (German Cancer Research Center)

  • Christof Niehrs

    (German Cancer Research Center)

Abstract

DNA methylation reversed It is increasingly appreciated that DNA methylation, a ubiquitous regulatory mechanism, can be reversed by a process termed 'active demethylation', but its underlying mechanism is poorly understood. Advance in the DNA demethylation field is hampered by a lack of knowledge about the key regulators that could serve as a starting point for unravelling this process. Barreto et al. now report the discovery of one such regulator, Gadd45a, or growth arrest and DNA damage inducible protein 45-alpha. Gadd45a, shown previously to be a target of the p53 and BRCA1 tumour suppressor genes, is acting here by promoting DNA repair to erase methylation marks and thus relieve gene silencing.

Suggested Citation

  • Guillermo Barreto & Andrea Schäfer & Joachim Marhold & Dirk Stach & Suresh K. Swaminathan & Vikas Handa & Gabi Döderlein & Nicole Maltry & Wei Wu & Frank Lyko & Christof Niehrs, 2007. "Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation," Nature, Nature, vol. 445(7128), pages 671-675, February.
    • Handle: RePEc:nat:nature:v:445:y:2007:i:7128:d:10.1038_nature05515
    DOI: 10.1038/nature05515
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature05515
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature05515?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:445:y:2007:i:7128:d:10.1038_nature05515. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.