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bicoid RNA localization requires specific binding of an endosomal sorting complex

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  • Uwe Irion

    (University of Cambridge
    Max-Planck-Institut für Entwicklungsbiologie)

  • Daniel St Johnston

    (University of Cambridge)

Abstract

Fronting up Although bicoid mRNA, the anterior determinant of Drosophila, was the first localized determinant to be identified, it is unclear how it targets the anterior of the Drosophila egg. Uwe Irion and Daniel St Johnston have now identified the specificity factor that couples the RNA to the localization pathway as the ESCRT-II complex. ESCRT-II is involved in sorting proteins endocytosed from the cell surface into the degradation pathway, and also acts as a tumour suppressor. Localization of bicoid mRNA is independent of endosomal sorting, and as rat ESCRT-II also binds RNA, this novel function in mRNA localization appears to be conserved in mammals.

Suggested Citation

  • Uwe Irion & Daniel St Johnston, 2007. "bicoid RNA localization requires specific binding of an endosomal sorting complex," Nature, Nature, vol. 445(7127), pages 554-558, February.
    • Handle: RePEc:nat:nature:v:445:y:2007:i:7127:d:10.1038_nature05503
    DOI: 10.1038/nature05503
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