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Sonic hedgehog function in chondrichthyan fins and the evolution of appendage patterning

Author

Listed:
  • Randall D. Dahn

    (The University of Chicago)

  • Marcus C. Davis

    (The University of Chicago)

  • William N. Pappano

    (The Johns Hopkins School of Medicine)

  • Neil H. Shubin

    (The University of Chicago
    Field Museum of Natural History)

Abstract

Out on a fin A key question in the evolution of limbs and fins is the generality of the genetic mechanism underlying their development. Following reports that shark fins developed without Sonic hedgehog (Shh), a gene elsewhere seen as crucial to the process, Dahn et al. re-investigated the problem. They find that Shh is indeed involved in shark fin development, boosting its credentials as a key component of anteroposterior patterning of vertebrate fins and limbs.

Suggested Citation

  • Randall D. Dahn & Marcus C. Davis & William N. Pappano & Neil H. Shubin, 2007. "Sonic hedgehog function in chondrichthyan fins and the evolution of appendage patterning," Nature, Nature, vol. 445(7125), pages 311-314, January.
    • Handle: RePEc:nat:nature:v:445:y:2007:i:7125:d:10.1038_nature05436
    DOI: 10.1038/nature05436
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