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A systems biology analysis of the Drosophila phagosome

Author

Listed:
  • L. M. Stuart

    (Massachusetts General Hospital/ Harvard Medical School
    The University of Edinburgh, The Queen’s Medical Research Institute)

  • J. Boulais

    (Université de Montréal)

  • G. M. Charriere

    (Massachusetts General Hospital/ Harvard Medical School)

  • E. J. Hennessy

    (Massachusetts General Hospital/ Harvard Medical School)

  • S. Brunet

    (Université de Montréal)

  • I. Jutras

    (Université de Montréal)

  • G. Goyette

    (Université de Montréal)

  • C. Rondeau

    (Université de Montréal)

  • S. Letarte

    (Université de Montréal)

  • H. Huang

    (Johns Hopkins University)

  • P. Ye

    (Johns Hopkins University)

  • F. Morales

    (McGill University)

  • C. Kocks

    (Massachusetts General Hospital/ Harvard Medical School)

  • J. S. Bader

    (Johns Hopkins University)

  • M. Desjardins

    (Université de Montréal)

  • R. A. B. Ezekowitz

    (Massachusetts General Hospital/ Harvard Medical School
    Merck Research Laboratories, RY80K-107)

Abstract

Anatomy of the phagosome The phagocytes in our blood-stream are central to our defence against pathogens: they bind and internalize bacteria into a subcellular compartment termed the phagosome where they are destroyed. Some pathogens have evolved strategies to evade this process, so a better understanding of how phagocytosis is regulated is important for the study of host–pathogen interactions and innate immunity. Using a systems biology approach, Stuart et al. identified over 600 phagosome-related proteins in Drosophila, and analysed many of the proteins' complex interactions. The result is a detailed model of the phagosome and regulators of bacterial engulfment.

Suggested Citation

  • L. M. Stuart & J. Boulais & G. M. Charriere & E. J. Hennessy & S. Brunet & I. Jutras & G. Goyette & C. Rondeau & S. Letarte & H. Huang & P. Ye & F. Morales & C. Kocks & J. S. Bader & M. Desjardins & R, 2007. "A systems biology analysis of the Drosophila phagosome," Nature, Nature, vol. 445(7123), pages 95-101, January.
    • Handle: RePEc:nat:nature:v:445:y:2007:i:7123:d:10.1038_nature05380
    DOI: 10.1038/nature05380
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