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Hsp70 regulates erythropoiesis by preventing caspase-3-mediated cleavage of GATA-1

Author

Listed:
  • Jean-Antoine Ribeil

    (Institut Fédérative Necker)

  • Yael Zermati

    (Institut Fédérative Necker
    INSERM UMR 517)

  • Julie Vandekerckhove

    (Institut Fédérative Necker)

  • Severine Cathelin

    (INSERM UMR 517)

  • Joelle Kersual

    (Institut Fédérative Necker)

  • Michaël Dussiot

    (Institut Fédérative Necker)

  • Séverine Coulon

    (Institut Fédérative Necker)

  • Ivan Cruz Moura

    (Institut Fédérative Necker)

  • Ann Zeuner

    (Istituto Superiore di Santia)

  • Thomas Kirkegaard-Sørensen

    (Institute for Cancer Biology, Danish Cancer Society)

  • Bruno Varet

    (Institut Fédérative Necker
    Faculté de Médecine et Université René Descartes Paris V, Assistance publique des hôpitaux de Paris, Necker)

  • Eric Solary

    (INSERM UMR 517)

  • Carmen Garrido

    (INSERM UMR 517)

  • Olivier Hermine

    (Institut Fédérative Necker
    Faculté de Médecine et Université René Descartes Paris V, Assistance publique des hôpitaux de Paris, Necker)

Abstract

The heat-shock protein Hsp70 can regulate the development of red blood cells, or erythropoiesis. Hsp70 interacts with GATA-1 and protects it from cleavage, thus controlling the differentiation of erythrocytes by its presence in the nucleus.

Suggested Citation

  • Jean-Antoine Ribeil & Yael Zermati & Julie Vandekerckhove & Severine Cathelin & Joelle Kersual & Michaël Dussiot & Séverine Coulon & Ivan Cruz Moura & Ann Zeuner & Thomas Kirkegaard-Sørensen & Bruno V, 2007. "Hsp70 regulates erythropoiesis by preventing caspase-3-mediated cleavage of GATA-1," Nature, Nature, vol. 445(7123), pages 102-105, January.
    • Handle: RePEc:nat:nature:v:445:y:2007:i:7123:d:10.1038_nature05378
    DOI: 10.1038/nature05378
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