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Mechanisms linking obesity with cardiovascular disease

Author

Listed:
  • Luc F. Van Gaal

    (University of Antwerp, Faculty of Medicine, Metabolism and Clinical Nutrition, Antwerp University Hospital, Wilrijkstraat 10)

  • Ilse L. Mertens

    (University of Antwerp, Faculty of Medicine, Metabolism and Clinical Nutrition, Antwerp University Hospital, Wilrijkstraat 10)

  • Christophe E. De Block

    (University of Antwerp, Faculty of Medicine, Metabolism and Clinical Nutrition, Antwerp University Hospital, Wilrijkstraat 10)

Abstract

Obesity increases the risk of cardiovascular disease and premature death. Adipose tissue releases a large number of bioactive mediators that influence not only body weight homeostasis but also insulin resistance — the core feature of type 2 diabetes — as well as alterations in lipids, blood pressure, coagulation, fibrinolysis and inflammation, leading to endothelial dysfunction and atherosclerosis. We are now beginning to understand the underlying mechanisms as well as the ways in which smoking and dyslipidaemia increase, and physical activity attenuates, the adverse effects of obesity on cardiovascular health.

Suggested Citation

  • Luc F. Van Gaal & Ilse L. Mertens & Christophe E. De Block, 2006. "Mechanisms linking obesity with cardiovascular disease," Nature, Nature, vol. 444(7121), pages 875-880, December.
    • Handle: RePEc:nat:nature:v:444:y:2006:i:7121:d:10.1038_nature05487
    DOI: 10.1038/nature05487
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