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The cytohesin Steppke is essential for insulin signalling in Drosophila

Author

Listed:
  • Bernhard Fuss

    (University of Bonn)

  • Thomas Becker

    (University of Bonn)

  • Ingo Zinke

    (University of Bonn)

  • Michael Hoch

    (University of Bonn)

Abstract

Cytohesins and insulin Insulin resistance syndrome, a condition in which various organs respond insufficiently to insulin, is a major risk factor for the development of type 2 diabetes. For the majority of affected individuals, the underlying molecular defects are unknown. Hafner et al. now show that chemical inhibition of cytohesins, regulatory proteins not previously implicated in insulin-regulated metabolism, induces hepatic insulin resistance in mice. This points to impaired cytohesin function as a possible cause for insulin resistance and to cytohesin activators as a treatment for this disease. In a separate study the Drosophila cytohesin equivalent Steppke is shown to be an essential component of insulin signalling. Taken together, the two papers provide independent evidence for the involvement of cytohesins in the insulin pathway and demonstrate that the cytohesin-mediated control of this pathway is at least 800 million years old.

Suggested Citation

  • Bernhard Fuss & Thomas Becker & Ingo Zinke & Michael Hoch, 2006. "The cytohesin Steppke is essential for insulin signalling in Drosophila," Nature, Nature, vol. 444(7121), pages 945-948, December.
    • Handle: RePEc:nat:nature:v:444:y:2006:i:7121:d:10.1038_nature05412
    DOI: 10.1038/nature05412
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