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Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism

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  • Yuequan Shen

    (The University of Chicago)

  • Andrzej Joachimiak

    (Argonne National Laboratory)

  • Marsha Rich Rosner

    (The University of Chicago)

  • Wei-Jen Tang

    (The University of Chicago)

Abstract

Amyloid clearance Insulin-degrading enzyme (IDE) is involved in the clearance of insulin and amyloid β. This is necessary to maintain proper blood sugar levels and to prevent accumulation of amyloid β in the brain. The crystal structure of IDE in complex with four substrates has now been determined, revealing the molecular basis for substrate recognition. This should aid the design of IDE-based drugs for Alzheimer's disease and type II diabetes.

Suggested Citation

  • Yuequan Shen & Andrzej Joachimiak & Marsha Rich Rosner & Wei-Jen Tang, 2006. "Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism," Nature, Nature, vol. 443(7113), pages 870-874, October.
    • Handle: RePEc:nat:nature:v:443:y:2006:i:7113:d:10.1038_nature05143
    DOI: 10.1038/nature05143
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