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Sodium-dependent uptake of inorganic phosphate by the intracellular malaria parasite

Author

Listed:
  • Kevin J. Saliba

    (School of Biochemistry and Molecular Biology
    Medical School, The Australian National University)

  • Rowena E. Martin

    (School of Biochemistry and Molecular Biology)

  • Angelika Bröer

    (School of Biochemistry and Molecular Biology)

  • Roselani I. Henry

    (School of Biochemistry and Molecular Biology)

  • C. Siobhan McCarthy

    (School of Biochemistry and Molecular Biology)

  • Megan J. Downie

    (School of Biochemistry and Molecular Biology)

  • Richard J. W. Allen

    (School of Biochemistry and Molecular Biology)

  • Kylie A. Mullin

    (University of Melbourne)

  • Geoffrey I. McFadden

    (University of Melbourne)

  • Stefan Bröer

    (School of Biochemistry and Molecular Biology)

  • Kiaran Kirk

    (School of Biochemistry and Molecular Biology)

Abstract

The unusual channels It's been known for some time that the malaria parasite induces or activates novel channels in the membrane of its host red blood cell, and that because of this, Na+ moves into the red cell cytosol, making it a high-Na+ environment. New work shows that the parasite takes advantage of this raised Na+ to energize the uptake of an essential nutrient, inorganic phosphate. Now the Na+-coupled transporter protein involved has been identified.

Suggested Citation

  • Kevin J. Saliba & Rowena E. Martin & Angelika Bröer & Roselani I. Henry & C. Siobhan McCarthy & Megan J. Downie & Richard J. W. Allen & Kylie A. Mullin & Geoffrey I. McFadden & Stefan Bröer & Kiaran K, 2006. "Sodium-dependent uptake of inorganic phosphate by the intracellular malaria parasite," Nature, Nature, vol. 443(7111), pages 582-585, October.
    • Handle: RePEc:nat:nature:v:443:y:2006:i:7111:d:10.1038_nature05149
    DOI: 10.1038/nature05149
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