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Increased outcrossing in hothead mutants

Author

Listed:
  • Peng Peng

    (Howard Hughes Medical Institute, University of California
    Cell and Developmental Biology, University of California)

  • Simon W.-L. Chan

    (Cell and Developmental Biology, University of California
    University of California)

  • Govind A. Shah

    (Cell and Developmental Biology, University of California)

  • Steve E. Jacobsen

    (Howard Hughes Medical Institute, University of California
    Cell and Developmental Biology, University of California)

Abstract

Arising from: S. J. Lolle, J. L. Victor, J. M. Young & R. E. Pruitt Nature 434, 505–509 (2005); Lolle et al. reply Lolle et al.1 report that loss-of-function alleles of the HOTHEAD (HTH) gene in Arabidopsis thaliana are genetically unstable, giving rise to wild-type revertants. On the basis of the reversion of many other genetic markers in hth plants, they suggested a model in which a cache of extragenomic information could cause genes to revert to the genotype of previous generations. In our attempts to reproduce this phenomenon, we discovered that hth mutants show a marked tendency to outcross (unlike wild-type A. thaliana, which is almost exclusively self-fertilizing2). Moreover, when hth plants are grown in isolation, their genetic inheritance is completely stable. These results may provide an alternative explanation for the genome wide non-mendelian inheritance reported by Lolle et al.

Suggested Citation

  • Peng Peng & Simon W.-L. Chan & Govind A. Shah & Steve E. Jacobsen, 2006. "Increased outcrossing in hothead mutants," Nature, Nature, vol. 443(7110), pages 8-8, September.
    • Handle: RePEc:nat:nature:v:443:y:2006:i:7110:d:10.1038_nature05251
    DOI: 10.1038/nature05251
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