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Topical drug rescue strategy and skin protection based on the role of Mc1r in UV-induced tanning

Author

Listed:
  • John A. D'Orazio

    (Melanoma Program
    Dana-Farber Cancer Institute & Children's Hospital
    Children's Hospital
    Markey Cancer Center and the Graduate Center for Toxicology, University of Kentucky College of Medicine)

  • Tetsuji Nobuhisa

    (Melanoma Program
    Dana-Farber Cancer Institute & Children's Hospital
    Children's Hospital)

  • Rutao Cui

    (Melanoma Program
    Dana-Farber Cancer Institute & Children's Hospital
    Children's Hospital)

  • Michelle Arya

    (Melanoma Program
    Dana-Farber Cancer Institute & Children's Hospital
    Children's Hospital)

  • Malinda Spry

    (Markey Cancer Center and the Graduate Center for Toxicology, University of Kentucky College of Medicine)

  • Kazumasa Wakamatsu

    (Fujita Health University, School of Health Sciences)

  • Vivien Igras

    (Melanoma Program
    Dana-Farber Cancer Institute & Children's Hospital
    Children's Hospital)

  • Takahiro Kunisada

    (Gifu University, Graduate School of Medicine)

  • Scott R. Granter

    (Melanoma Program
    Brigham and Women's Hospital)

  • Emi K. Nishimura

    (Melanoma Program
    Dana-Farber Cancer Institute & Children's Hospital
    Children's Hospital
    Kanazawa University, Cancer Research Institute)

  • Shosuke Ito

    (Fujita Health University, School of Health Sciences)

  • David E. Fisher

    (Melanoma Program
    Dana-Farber Cancer Institute & Children's Hospital
    Children's Hospital)

Abstract

An antitumour tan? Fair-skinned individuals suffer an increased risk of skin cancer and often have a weak tanning response. D'Orazio et al. have developed a genetically defined mouse model of skin 'fairness' based on the Mc1r gene (for melanocortin 1 receptor), which is implicated in fair-skinned humans. UV-induced pigmentation (tanning) in these mice was found to involve keratinocyte expression of melanocyte stimulating hormone. 'Sunless tanning' induced by topical application of a small molecule that mimics this enhanced melanocortin 1 receptor signalling can stimulate pigmentation and thereby protect mice with light skin from DNA damage and cancer formation.

Suggested Citation

  • John A. D'Orazio & Tetsuji Nobuhisa & Rutao Cui & Michelle Arya & Malinda Spry & Kazumasa Wakamatsu & Vivien Igras & Takahiro Kunisada & Scott R. Granter & Emi K. Nishimura & Shosuke Ito & David E. Fi, 2006. "Topical drug rescue strategy and skin protection based on the role of Mc1r in UV-induced tanning," Nature, Nature, vol. 443(7109), pages 340-344, September.
    • Handle: RePEc:nat:nature:v:443:y:2006:i:7109:d:10.1038_nature05098
    DOI: 10.1038/nature05098
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