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Molecular identification of the CRAC channel by altered ion selectivity in a mutant of Orai

Author

Listed:
  • Andriy V. Yeromin

    (University of California
    University of California)

  • Shenyuan L. Zhang

    (University of California
    University of California)

  • Weihua Jiang

    (University of California
    University of California)

  • Ying Yu

    (University of California
    University of California)

  • Olga Safrina

    (University of California
    University of California)

  • Michael D. Cahalan

    (University of California
    University of California)

Abstract

Calcium pump Two groups report the molecular identification of the long-sought CRAC channel as a plasma membrane protein known variously as olf186-F, Orai and CRACM1. The CRAC channel is of fundamental importance to Ca2+ signalling mechanisms in cell biology.

Suggested Citation

  • Andriy V. Yeromin & Shenyuan L. Zhang & Weihua Jiang & Ying Yu & Olga Safrina & Michael D. Cahalan, 2006. "Molecular identification of the CRAC channel by altered ion selectivity in a mutant of Orai," Nature, Nature, vol. 443(7108), pages 226-229, September.
    • Handle: RePEc:nat:nature:v:443:y:2006:i:7108:d:10.1038_nature05108
    DOI: 10.1038/nature05108
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