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Structure of the insulin receptor ectodomain reveals a folded-over conformation

Author

Listed:
  • Neil M. McKern

    (CSIRO Molecular & Health Technologies
    Health Technologies)

  • Michael C. Lawrence

    (CSIRO Molecular & Health Technologies
    Health Technologies)

  • Victor A. Streltsov

    (CSIRO Molecular & Health Technologies
    Health Technologies)

  • Mei-Zhen Lou

    (CSIRO Molecular & Health Technologies
    Health Technologies)

  • Timothy E. Adams

    (CSIRO Molecular & Health Technologies
    Health Technologies)

  • George O. Lovrecz

    (CSIRO Molecular & Health Technologies
    Health Technologies)

  • Thomas C. Elleman

    (CSIRO Molecular & Health Technologies
    Health Technologies)

  • Kim M. Richards

    (CSIRO Molecular & Health Technologies
    Health Technologies)

  • John D. Bentley

    (CSIRO Molecular & Health Technologies
    Health Technologies)

  • Patricia A. Pilling

    (CSIRO Molecular & Health Technologies
    Health Technologies)

  • Peter A. Hoyne

    (CSIRO Molecular & Health Technologies
    Health Technologies)

  • Kellie A. Cartledge

    (CSIRO Molecular & Health Technologies
    Health Technologies)

  • Tam M. Pham

    (CSIRO Molecular & Health Technologies
    Health Technologies)

  • Jennifer L. Lewis

    (CSIRO Molecular & Health Technologies
    Health Technologies)

  • Sonia E. Sankovich

    (CSIRO Molecular & Health Technologies
    Health Technologies)

  • Violet Stoichevska

    (CSIRO Molecular & Health Technologies
    Health Technologies)

  • Elizabeth Da Silva

    (CSIRO Molecular & Health Technologies
    Health Technologies)

  • Christine P. Robinson

    (CSIRO Molecular & Health Technologies
    Health Technologies)

  • Maurice J. Frenkel

    (CSIRO Molecular & Health Technologies
    Health Technologies)

  • Lindsay G. Sparrow

    (CSIRO Molecular & Health Technologies
    Health Technologies)

  • Ross T. Fernley

    (CSIRO Molecular & Health Technologies
    Health Technologies)

  • V. Chandana Epa

    (CSIRO Molecular & Health Technologies
    Health Technologies)

  • Colin W. Ward

    (CSIRO Molecular & Health Technologies
    Health Technologies)

Abstract

Insulin receptor second site The first report of the crystal structure of the whole insulin receptor ectodomain dimer reveals how its multiple domains are organized. The structure also identifies the elusive second binding site on the receptor, and suggests how the high-affinity insulin–receptor complex, which leads to signal induction, is generated. The structure as now published differs dramatically from previous versions based on reconstructions from cryoelectron microscopy data.

Suggested Citation

  • Neil M. McKern & Michael C. Lawrence & Victor A. Streltsov & Mei-Zhen Lou & Timothy E. Adams & George O. Lovrecz & Thomas C. Elleman & Kim M. Richards & John D. Bentley & Patricia A. Pilling & Peter A, 2006. "Structure of the insulin receptor ectodomain reveals a folded-over conformation," Nature, Nature, vol. 443(7108), pages 218-221, September.
    • Handle: RePEc:nat:nature:v:443:y:2006:i:7108:d:10.1038_nature05106
    DOI: 10.1038/nature05106
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    Cited by:

    1. Junhee Park & Jie Li & John P. Mayer & Kerri A. Ball & Jiayi Wu & Catherine Hall & Domenico Accili & Michael H. B. Stowell & Xiao-chen Bai & Eunhee Choi, 2022. "Activation of the insulin receptor by an insulin mimetic peptide," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    2. Nicholas S. Kirk & Qi Chen & Yingzhe Ginger Wu & Anastasia L. Asante & Haitao Hu & Juan F. Espinosa & Francisco Martínez-Olid & Mai B. Margetts & Faiz A. Mohammed & Vladislav V. Kiselyov & David G. Ba, 2022. "Activation of the human insulin receptor by non-insulin-related peptides," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    3. Junhong Kim & Na-Oh Yunn & Mangeun Park & Jihan Kim & Seongeun Park & Yoojoong Kim & Jeongeun Noh & Sung Ho Ryu & Yunje Cho, 2022. "Functional selectivity of insulin receptor revealed by aptamer-trapped receptor structures," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    4. Weidong An & Catherine Hall & Jie Li & Albert Hung & Jiayi Wu & Junhee Park & Liwei Wang & Xiao-chen Bai & Eunhee Choi, 2024. "Activation of the insulin receptor by insulin-like growth factor 2," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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