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Sperm chromatin proteomics identifies evolutionarily conserved fertility factors

Author

Listed:
  • Diana S. Chu

    (San Francisco State University)

  • Hongbin Liu

    (The Scripps Research Institute
    Agilent Technologies, Inc.)

  • Paola Nix

    (University of California, Berkeley
    Howard Hughes Medical Institute)

  • Tammy F. Wu

    (San Francisco State University)

  • Edward J. Ralston

    (University of California, Berkeley
    Howard Hughes Medical Institute)

  • John R. Yates III

    (The Scripps Research Institute)

  • Barbara J. Meyer

    (University of California, Berkeley
    Howard Hughes Medical Institute)

Abstract

Fertility factors The identification of conserved proteins important for sperm chromatin structure and packaging can reveal possible causes of male fertility of clinical importance. A proteomics strategy in the nematode Caenorhabditis elegans has been used to identify a series of spermatogenesis-specific factors that are required for DNA compaction, chromosome segregation and fertility, many of which cause male sterility in mice. The resulting list of proteins will provide new opportunities to identify the causes of male sterility and could also provide possible targets for male contraceptives. The cover image shows nuclei progressing through spermatogenesis in a C. elegans male gonad, which has been fixed and stained with fluorescent markers. DNA is shown in red. Sperm protamines SPCH-1, SPCH-2 and SPCH-3 are shown in green. Yellow in the image indicates colocalization.

Suggested Citation

  • Diana S. Chu & Hongbin Liu & Paola Nix & Tammy F. Wu & Edward J. Ralston & John R. Yates III & Barbara J. Meyer, 2006. "Sperm chromatin proteomics identifies evolutionarily conserved fertility factors," Nature, Nature, vol. 443(7107), pages 101-105, September.
    • Handle: RePEc:nat:nature:v:443:y:2006:i:7107:d:10.1038_nature05050
    DOI: 10.1038/nature05050
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