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Nondisjunction, aneuploidy and tetraploidy

Author

Listed:
  • Beth A. A. Weaver

    (University of California, San Diego)

  • Alain D. Silk

    (University of California, San Diego)

  • Don W. Cleveland

    (University of California, San Diego)

Abstract

Arising from: Q. Shi & R. W. King Nature 437, 1038–1042 (2005); Shi & King reply One simple, widely accepted mechanism for generating an aberrant chromosome number, or aneuploidy, is through nondisjunction — a chromosome distribution error that occurs during mitosis when both copies of a duplicated chromosome are deposited into one daughter cell and none into the other. Shi and King1 challenge this view, concluding that nondisjunction does not yield aneuploid cells directly, but instead gives rise to tetraploid cells that may subsequently become aneuploid through further division. Here we show that the direct result of chromosome nondisjunction is gain or loss of a single chromosome, which results in near-diploid aneuploidy, not tetraploidy. We suggest that chromatin trapped in the cytokinetic cleavage furrow is the more likely reason for furrow regression and tetraploidization.

Suggested Citation

  • Beth A. A. Weaver & Alain D. Silk & Don W. Cleveland, 2006. "Nondisjunction, aneuploidy and tetraploidy," Nature, Nature, vol. 442(7104), pages 9-10, August.
    • Handle: RePEc:nat:nature:v:442:y:2006:i:7104:d:10.1038_nature05139
    DOI: 10.1038/nature05139
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