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Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-γ and PTEN

Author

Listed:
  • Min Zhao

    (University of Aberdeen)

  • Bing Song

    (University of Aberdeen)

  • Jin Pu

    (University of Aberdeen)

  • Teiji Wada

    (Institute of Molecular Biotechnology of the Austrian Academy of Sciences)

  • Brian Reid

    (University of Aberdeen)

  • Guangping Tai

    (University of Aberdeen)

  • Fei Wang

    (University of California
    University of Illinois, B107 Chemical and Life Sciences Laboratory)

  • Aihua Guo

    (University of Aberdeen)

  • Petr Walczysko

    (University of Aberdeen)

  • Yu Gu

    (University of Aberdeen)

  • Takehiko Sasaki

    (Akita University School of Medicine)

  • Akira Suzuki

    (Akita University School of Medicine)

  • John V. Forrester

    (University of Aberdeen)

  • Henry R. Bourne

    (University of California)

  • Peter N. Devreotes

    (Johns Hopkins University School of Medicine)

  • Colin D. McCaig

    (University of Aberdeen)

  • Josef M. Penninger

    (Institute of Molecular Biotechnology of the Austrian Academy of Sciences)

Abstract

Healing potential The disruption of the epithelium in all animals tested generates an endogenous electric current, and the cells involved in wound healing are known to respond to applied electrical signals. Wound-induced currents have been known for more than 150 years but their role in wound healing has largely been discounted. New work in mice and in tissue culture shows that electric fields can provide directional cues for cell movement during wound healing and identifies specific genes that are involved, which should lead to a more positive attitude to this intriguing phenomenon. The molecules central to this finding are phosphatidylinositol 3′-kinase-γ(PI3Kγ) and the tumour suppressor PTEN, which have been found to be required for the directed movements of 'healing' cells in response to electrical signals.

Suggested Citation

  • Min Zhao & Bing Song & Jin Pu & Teiji Wada & Brian Reid & Guangping Tai & Fei Wang & Aihua Guo & Petr Walczysko & Yu Gu & Takehiko Sasaki & Akira Suzuki & John V. Forrester & Henry R. Bourne & Peter N, 2006. "Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-γ and PTEN," Nature, Nature, vol. 442(7101), pages 457-460, July.
    • Handle: RePEc:nat:nature:v:442:y:2006:i:7101:d:10.1038_nature04925
    DOI: 10.1038/nature04925
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    Cited by:

    1. Himanshu Kaul & Zhanfeng Cui & Yiannis Ventikos, 2013. "A Multi-Paradigm Modeling Framework to Simulate Dynamic Reciprocity in a Bioreactor," PLOS ONE, Public Library of Science, vol. 8(3), pages 1-15, March.
    2. Gawoon Shim & Isaac B. Breinyn & Alejandro Martínez-Calvo & Sameeksha Rao & Daniel J. Cohen, 2024. "Bioelectric stimulation controls tissue shape and size," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    3. Nathan M. Belliveau & Matthew J. Footer & Emel Akdoǧan & Aaron P. Loon & Sean R. Collins & Julie A. Theriot, 2023. "Whole-genome screens reveal regulators of differentiation state and context-dependent migration in human neutrophils," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    4. Guang Yao & Xiaoyi Mo & Shanshan Liu & Qian Wang & Maowen Xie & Wenhao Lou & Shiyan Chen & Taisong Pan & Ke Chen & Dezhong Yao & Yuan Lin, 2023. "Snowflake-inspired and blink-driven flexible piezoelectric contact lenses for effective corneal injury repair," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    5. Tatsat Banerjee & Satomi Matsuoka & Debojyoti Biswas & Yuchuan Miao & Dhiman Sankar Pal & Yoichiro Kamimura & Masahiro Ueda & Peter N. Devreotes & Pablo A. Iglesias, 2023. "A dynamic partitioning mechanism polarizes membrane protein distribution," Nature Communications, Nature, vol. 14(1), pages 1-24, December.

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