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Kruppel-like factor 2 regulates thymocyte and T-cell migration

Author

Listed:
  • Corey M. Carlson

    (University of Minnesota Medical School)

  • Bart T. Endrizzi

    (University of Minnesota Medical School)

  • Jinghai Wu

    (University of Cincinnati)

  • Xiaojie Ding

    (University of Minnesota Medical School)

  • Michael A. Weinreich

    (University of Minnesota Medical School)

  • Elizabeth R. Walsh

    (University of Minnesota Medical School)

  • Maqsood A. Wani

    (University of Cincinnati)

  • Jerry B. Lingrel

    (University of Cincinnati)

  • Kristin A. Hogquist

    (University of Minnesota Medical School)

  • Stephen C. Jameson

    (University of Minnesota Medical School)

Abstract

A new role for KLF2 The transcription factor KLF2 has long been thought to play a critical role in controlling survival and quiescence of mature T cells, since KLF2-deficient T cells develop in the thymus but fail to populate peripheral lymph organs. A new study offers an alternative explanation for this phenotype, consistent with an entirely different function for KLF2 as a regulator of thymocyte and T-cell migration. Proteins of the KLF (Krüppel-like transcription factor) family are involved in many aspects of vertebrate development and are implicated in a number of disease states. This newly discovered role for KLF2 is similar to some other KLFs that are essential for terminal differentiation of various cell types.

Suggested Citation

  • Corey M. Carlson & Bart T. Endrizzi & Jinghai Wu & Xiaojie Ding & Michael A. Weinreich & Elizabeth R. Walsh & Maqsood A. Wani & Jerry B. Lingrel & Kristin A. Hogquist & Stephen C. Jameson, 2006. "Kruppel-like factor 2 regulates thymocyte and T-cell migration," Nature, Nature, vol. 442(7100), pages 299-302, July.
    • Handle: RePEc:nat:nature:v:442:y:2006:i:7100:d:10.1038_nature04882
    DOI: 10.1038/nature04882
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