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Atom-by-atom analysis of global downhill protein folding

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  • Mourad Sadqi

    (University of Maryland)

  • David Fushman

    (University of Maryland)

  • Victor Muñoz

    (University of Maryland)

Abstract

Atom-by-atom folding In the past, protein folding has been more approachable via theory than via experiment. But recently, theory has begun to be confirmed experimentally. In contrast to the belief that all proteins fold in one sudden movement, some in fact fold and unfold gradually, in a random series of steps called downhill folding. Sadqi et al. have used a novel NMR approach to monitor unfolding of a protein atom-by-atom from the native state. The results have greater resolution than had been previously achieved, and confirm that folding is a statistical process best understood by a downhill landscape funnel model. In addition, cooperativity can be understood by mapping the atomic interactions within a protein.

Suggested Citation

  • Mourad Sadqi & David Fushman & Victor Muñoz, 2006. "Atom-by-atom analysis of global downhill protein folding," Nature, Nature, vol. 442(7100), pages 317-321, July.
    • Handle: RePEc:nat:nature:v:442:y:2006:i:7100:d:10.1038_nature04859
    DOI: 10.1038/nature04859
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