IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v442y2006i7099d10.1038_nature04908.html
   My bibliography  Save this article

Does prepatterning occur in the mouse egg? (Reply)

Author

Listed:
  • Berenika Plusa

    (University of Cambridge)

  • Anna-Katerina Hadjantonakis

    (Developmental Biology Program, Sloan-Kettering Institute)

  • Dionne Gray

    (University of Cambridge)

  • Karolina Piotrowska-Nitsche

    (University of Cambridge)

  • Agnieszka Jedrusik

    (University of Cambridge)

  • Virginia E. Papaioannou

    (College of Physicians and Surgeons, Columbia University)

  • David M. Glover

    (University of Cambridge)

  • Magdalena Zernicka-Goetz

    (University of Cambridge)

Abstract

Hiiragi et al .1 compare our model2 of the developing mouse egg with theirs3. They seem to present patterning as equivalent to determination, but this is confusing as patterning does not have to mean determination. We have never stated that mouse embryo development is determined. Mouse development is regulative rather than determinative, and this can be explained in two ways: first, development could be entirely unbiased, generating identical cells; second, there could be some developmental bias or, in other words, pattern from the beginning that is not constraining. There is evidence for early bias from several laboratories2,4,5,6,7,8 but this does not mean that cells have localized determinants fixing their fates. Regulative development does not exclude bias, which indicates inclination, not determination.

Suggested Citation

  • Berenika Plusa & Anna-Katerina Hadjantonakis & Dionne Gray & Karolina Piotrowska-Nitsche & Agnieszka Jedrusik & Virginia E. Papaioannou & David M. Glover & Magdalena Zernicka-Goetz, 2006. "Does prepatterning occur in the mouse egg? (Reply)," Nature, Nature, vol. 442(7099), pages 4-4, July.
    • Handle: RePEc:nat:nature:v:442:y:2006:i:7099:d:10.1038_nature04908
    DOI: 10.1038/nature04908
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature04908
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature04908?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:442:y:2006:i:7099:d:10.1038_nature04908. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.