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Stem cells, ageing and the quest for immortality

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  • Thomas A. Rando

    (Geriatric Research, Education and Clinical Center (GRECC), VA Palo Alto Health Care System, Stanford University School of Medicine)

Abstract

Listen to an interview with Tom Rando on the stem cells podcast Adult stem cells reside in most mammalian tissues, but the extent to which they contribute to normal homeostasis and repair varies widely. There is an overall decline in tissue regenerative potential with age, and the question arises as to whether this is due to the intrinsic ageing of stem cells or, rather, to the impairment of stem-cell function in the aged tissue environment. Unravelling these distinct contributions to the aged phenotype will be critical to the success of any therapeutic application of stem cells in the emerging field of regenerative medicine with respect to tissue injury, degenerative diseases or normal functional declines that accompany ageing.

Suggested Citation

  • Thomas A. Rando, 2006. "Stem cells, ageing and the quest for immortality," Nature, Nature, vol. 441(7097), pages 1080-1086, June.
    • Handle: RePEc:nat:nature:v:441:y:2006:i:7097:d:10.1038_nature04958
    DOI: 10.1038/nature04958
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    Cited by:

    1. Sharif M. Ridwan & Autumn Twillie & Samaneh Poursaeid & Emma Kristine Beard & Muhammed Burak Bener & Matthew Antel & Ann E. Cowan & Shinya Matsuda & Mayu Inaba, 2024. "Diffusible fraction of niche BMP ligand safeguards stem-cell differentiation," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    2. Aithal, Sreeramana & Aithal, Shubhrajyotsna, 2015. "A Review on Anticipated Breakthrough Technologies of 21st Century," MPRA Paper 71382, University Library of Munich, Germany.

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