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Formation of a functional thymus initiated by a postnatal epithelial progenitor cell

Author

Listed:
  • Conrad C. Bleul

    (Max-Planck Institute of Immunobiology)

  • Tatiana Corbeaux

    (Max-Planck Institute of Immunobiology)

  • Alexander Reuter

    (Max-Planck Institute of Immunobiology
    University of Konstanz)

  • Paul Fisch

    (University of Freiburg)

  • Jürgen Schulte Mönting

    (University of Freiburg)

  • Thomas Boehm

    (Max-Planck Institute of Immunobiology)

Abstract

Immune responses: two for T The thymus is the main source of T cells that form a major pillar of immune defence against viruses and cancerous cells. It is composed of two epithelial cell types — cortical and medullary — each of which performs distinct tasks in T-cell selection. Whether the two compartments arise from distinct or common progenitors has been controversial. Two groups, working separately, now show that there is a common progenitor for the two tissue types. The fact that a single precursor with stem-cell-like properties can generate both tissues provides hope for the viability of cell-based therapies for thymic disorders.

Suggested Citation

  • Conrad C. Bleul & Tatiana Corbeaux & Alexander Reuter & Paul Fisch & Jürgen Schulte Mönting & Thomas Boehm, 2006. "Formation of a functional thymus initiated by a postnatal epithelial progenitor cell," Nature, Nature, vol. 441(7096), pages 992-996, June.
    • Handle: RePEc:nat:nature:v:441:y:2006:i:7096:d:10.1038_nature04850
    DOI: 10.1038/nature04850
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