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Clonal analysis reveals a common progenitor for thymic cortical and medullary epithelium

Author

Listed:
  • Simona W. Rossi

    (Institute for Biomedical Research, Medical School, University of Birmingham)

  • William E. Jenkinson

    (Institute for Biomedical Research, Medical School, University of Birmingham)

  • Graham Anderson

    (Institute for Biomedical Research, Medical School, University of Birmingham)

  • Eric J. Jenkinson

    (Institute for Biomedical Research, Medical School, University of Birmingham)

Abstract

Immune responses: two for T The thymus is the main source of T cells that form a major pillar of immune defence against viruses and cancerous cells. It is composed of two epithelial cell types — cortical and medullary — each of which performs distinct tasks in T-cell selection. Whether the two compartments arise from distinct or common progenitors has been controversial. Two groups, working separately, now show that there is a common progenitor for the two tissue types. The fact that a single precursor with stem-cell-like properties can generate both tissues provides hope for the viability of cell-based therapies for thymic disorders.

Suggested Citation

  • Simona W. Rossi & William E. Jenkinson & Graham Anderson & Eric J. Jenkinson, 2006. "Clonal analysis reveals a common progenitor for thymic cortical and medullary epithelium," Nature, Nature, vol. 441(7096), pages 988-991, June.
    • Handle: RePEc:nat:nature:v:441:y:2006:i:7096:d:10.1038_nature04813
    DOI: 10.1038/nature04813
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