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Signal peptide peptidase is required for dislocation from the endoplasmic reticulum

Author

Listed:
  • Joana Loureiro

    (Department of Pathology
    Whitehead Institute for Biomedical Research
    Harvard University)

  • Brendan N. Lilley

    (Department of Pathology
    Whitehead Institute for Biomedical Research
    Harvard University)

  • Eric Spooner

    (Pathology Functional Proteomics Center, Harvard Medical School
    Whitehead Institute for Biomedical Research
    Harvard University)

  • Vanessa Noriega

    (Mount Sinai School of Medicine)

  • Domenico Tortorella

    (Mount Sinai School of Medicine)

  • Hidde L. Ploegh

    (Department of Pathology
    Whitehead Institute for Biomedical Research
    Harvard University)

Abstract

As well as cleaving hydrophobic stretches of amino acids in the plane of the cell membrane, the protease signal peptide peptidase plays a role in the disposal of unwanted glycoproteins from the endoplasmic reticulum — indicating that these proteases may be important for general membrane protein quality control.

Suggested Citation

  • Joana Loureiro & Brendan N. Lilley & Eric Spooner & Vanessa Noriega & Domenico Tortorella & Hidde L. Ploegh, 2006. "Signal peptide peptidase is required for dislocation from the endoplasmic reticulum," Nature, Nature, vol. 441(7095), pages 894-897, June.
  • Handle: RePEc:nat:nature:v:441:y:2006:i:7095:d:10.1038_nature04830
    DOI: 10.1038/nature04830
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    Cited by:

    1. Jian Yang & Niu Zhai & Yuhui Chen & Luying Wang & Rujin Chen & Huairong Pan, 2023. "A signal peptide peptidase is required for ER-symbiosome proximal association and protein secretion," Nature Communications, Nature, vol. 14(1), pages 1-11, December.

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