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Germline transmission of genetically modified primordial germ cells

Author

Listed:
  • Marie-Cecile van de Lavoir

    (Origen Therapeutics)

  • Jennifer H. Diamond

    (Origen Therapeutics)

  • Philip A. Leighton

    (Origen Therapeutics)

  • Christine Mather-Love

    (Origen Therapeutics)

  • Babette S. Heyer

    (Origen Therapeutics)

  • Renee Bradshaw

    (Origen Therapeutics)

  • Allyn Kerchner

    (Origen Therapeutics)

  • Lisa T. Hooi

    (Origen Therapeutics)

  • Terri M. Gessaro

    (University of California)

  • Susan E. Swanberg

    (University of California)

  • Mary E. Delany

    (University of California)

  • Robert J. Etches

    (Origen Therapeutics)

Abstract

Primordial germ cells (PGCs) can be isolated from chicken blood, propagated in culture indefinitely, and genetically modified to make transgenic chickens — in addition, the chicken PGCs can be induced in vivo to differentiate into embryonic germ cells that contribute to somatic tissues.

Suggested Citation

  • Marie-Cecile van de Lavoir & Jennifer H. Diamond & Philip A. Leighton & Christine Mather-Love & Babette S. Heyer & Renee Bradshaw & Allyn Kerchner & Lisa T. Hooi & Terri M. Gessaro & Susan E. Swanberg, 2006. "Germline transmission of genetically modified primordial germ cells," Nature, Nature, vol. 441(7094), pages 766-769, June.
    • Handle: RePEc:nat:nature:v:441:y:2006:i:7094:d:10.1038_nature04831
    DOI: 10.1038/nature04831
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