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Assembly of the inner rod determines needle length in the type III secretion injectisome

Author

Listed:
  • Thomas C. Marlovits

    (Section of Microbial Pathogenesis, Yale University School of Medicine, Boyer Center for Molecular Medicine
    Yale University School of Medicine
    Research Institute of Molecular Pathology (IMP) and Institute of Molecular Biotechnology, Austrian Academy of Sciences (IMBA)
    21st Century COE Program, Combined Program on Microbiology and Immunology, Osaka University)

  • Tomoko Kubori

    (Section of Microbial Pathogenesis, Yale University School of Medicine, Boyer Center for Molecular Medicine
    Research Institute of Molecular Pathology (IMP) and Institute of Molecular Biotechnology, Austrian Academy of Sciences (IMBA)
    21st Century COE Program, Combined Program on Microbiology and Immunology, Osaka University)

  • María Lara-Tejero

    (Section of Microbial Pathogenesis, Yale University School of Medicine, Boyer Center for Molecular Medicine)

  • Dennis Thomas

    (Howard Hughes Medical Institute, Rosenstiel Basic Medical Sciences Research Center, Brandeis University)

  • Vinzenz M. Unger

    (Yale University School of Medicine)

  • Jorge E. Galán

    (Section of Microbial Pathogenesis, Yale University School of Medicine, Boyer Center for Molecular Medicine)

Abstract

Needle match The needle complex or ‘injectisome’ that transfers proteins from bacteria to eukaryotic cells is a virulence factor in many bacterial pathogens. A new study of the Salmonella typhimurium injectisome throws light on the mechanism by which ‘needles’ are produced with the appropriate length.

Suggested Citation

  • Thomas C. Marlovits & Tomoko Kubori & María Lara-Tejero & Dennis Thomas & Vinzenz M. Unger & Jorge E. Galán, 2006. "Assembly of the inner rod determines needle length in the type III secretion injectisome," Nature, Nature, vol. 441(7093), pages 637-640, June.
    • Handle: RePEc:nat:nature:v:441:y:2006:i:7093:d:10.1038_nature04822
    DOI: 10.1038/nature04822
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    Cited by:

    1. Maulik K Nariya & Johnny Israeli & Jack J Shi & Eric J Deeds, 2016. "Mathematical Model for Length Control by the Timing of Substrate Switching in the Type III Secretion System," PLOS Computational Biology, Public Library of Science, vol. 12(4), pages 1-14, April.

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