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Ras, PI(3)K and mTOR signalling controls tumour cell growth

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  • Reuben J. Shaw

    (Dulbecco Laboratory for Cancer Research, The Salk Institute)

  • Lewis C. Cantley

    (Harvard Medical School, Beth Israel Deaconess Medical Center)

Abstract

All eukaryotic cells coordinate cell growth with the availability of nutrients in their environment. The mTOR protein kinase has emerged as a critical growth-control node, receiving stimulatory signals from Ras and phosphatidylinositol-3-OH kinase (PI(3)K) downstream from growth factors, as well as nutrient inputs in the form of amino-acid, glucose and oxygen availability. Notably, components of the Ras and PI(3)K signalling pathways are mutated in most human cancers. The preponderance of mutations in these interconnected pathways suggests that the loss of growth-control checkpoints and promotion of cell survival in nutrient-limited conditions may be an obligate event in tumorigenesis.

Suggested Citation

  • Reuben J. Shaw & Lewis C. Cantley, 2006. "Ras, PI(3)K and mTOR signalling controls tumour cell growth," Nature, Nature, vol. 441(7092), pages 424-430, May.
    • Handle: RePEc:nat:nature:v:441:y:2006:i:7092:d:10.1038_nature04869
    DOI: 10.1038/nature04869
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    Cited by:

    1. Noriyuki Uchida & Ai Kohata & Kou Okuro & Annalisa Cardellini & Chiara Lionello & Eric A. Zizzi & Marco A. Deriu & Giovanni M. Pavan & Michio Tomishige & Takaaki Hikima & Takuzo Aida, 2022. "Reconstitution of microtubule into GTP-responsive nanocapsules," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    2. Kai Yuan & Zhaoxing Li & Wenbin Kuang & Xiao Wang & Minghui Ji & Weijiao Chen & Jiayu Ding & Jiaxing Li & Wenjian Min & Chengliang Sun & Xiuquan Ye & Meiling Lu & Liping Wang & Haixia Ge & Yuzhang Jia, 2022. "Targeting dual-specificity tyrosine phosphorylation-regulated kinase 2 with a highly selective inhibitor for the treatment of prostate cancer," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    3. Guo-dong Cao & Xing-yu Xu & Jia-wei Zhang & Bo Chen & Mao-ming Xiong, 2016. "Phosphorylated Mammalian Target of Rapamycin p-mTOR Is a Favorable Prognostic Factor than mTOR in Gastric Cancer," PLOS ONE, Public Library of Science, vol. 11(12), pages 1-16, December.
    4. Pengyi Yang & Xiaofeng Zheng & Vivek Jayaswal & Guang Hu & Jean Yee Hwa Yang & Raja Jothi, 2015. "Knowledge-Based Analysis for Detecting Key Signaling Events from Time-Series Phosphoproteomics Data," PLOS Computational Biology, Public Library of Science, vol. 11(8), pages 1-18, August.

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