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Toll-like receptors and antibody responses (Reply)

Author

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  • C. Pasare

    (Howard Hughes Medical Institute and Section of Immunology, Yale University School of Medicine)

  • R. Medzhitov

    (Howard Hughes Medical Institute and Section of Immunology, Yale University School of Medicine)

Abstract

Using a range of different experimental approaches (and not just analyses of MyD88-deficient mice), we showed that, contrary to the prevailing view, a T-helper response is not sufficient for the generation of optimal T-dependent antibody responses, and that Toll-like-receptor (TLR) signalling in B cells is also required1. Similar results have since been obtained in human B cells2. Nemazee et al .3 now question our conclusions1.

Suggested Citation

  • C. Pasare & R. Medzhitov, 2006. "Toll-like receptors and antibody responses (Reply)," Nature, Nature, vol. 441(7091), pages 4-4, May.
    • Handle: RePEc:nat:nature:v:441:y:2006:i:7091:d:10.1038_nature04876
    DOI: 10.1038/nature04876
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