IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v441y2006i7091d10.1038_nature04875.html
   My bibliography  Save this article

Toll-like receptors and antibody responses

Author

Listed:
  • D. Nemazee

    (The Scripps Research Institute)

  • A. Gavin

    (The Scripps Research Institute)

  • K. Hoebe

    (The Scripps Research Institute)

  • B. Beutler

    (The Scripps Research Institute)

Abstract

Arising from: C. Pasare & R. Medzhitov Nature 438, 364–368 (2005); Pasare & Medzhitov reply . Microbial components, such as lipopolysaccharides, augment immune responses by activating Toll-like receptors (TLRs). Some have interpreted this to mean that TLR signalling might not only help to initiate the adaptive immune response, but may also be required for it1. The expanded view is shared by Pasare and Medzhitov2, who conclude from an analysis of mice deficient in MyD88 (a TLR-signalling adaptor protein) that the generation of T-dependent antigen-specific antibody responses requires activation of TLRs in B cells. However, we show here that robust antibody responses can be elicited even in the absence of TLR signals. This appreciable TLR-independence of immune responses should be taken into account in the rational design of immunogenic and toleragenic vaccines.

Suggested Citation

  • D. Nemazee & A. Gavin & K. Hoebe & B. Beutler, 2006. "Toll-like receptors and antibody responses," Nature, Nature, vol. 441(7091), pages 4-4, May.
    • Handle: RePEc:nat:nature:v:441:y:2006:i:7091:d:10.1038_nature04875
    DOI: 10.1038/nature04875
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature04875
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature04875?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:441:y:2006:i:7091:d:10.1038_nature04875. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.