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Hexon-chimaeric adenovirus serotype 5 vectors circumvent pre-existing anti-vector immunity

Author

Listed:
  • Diane M. Roberts

    (Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Anjali Nanda

    (Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Menzo J. E. Havenga

    (Crucell Holland BV)

  • Peter Abbink

    (Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Diana M. Lynch

    (Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Bonnie A. Ewald

    (Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Jinyan Liu

    (Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Anna R. Thorner

    (Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Patricia E. Swanson

    (Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Darci A. Gorgone

    (Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Michelle A. Lifton

    (Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Angelique A. C. Lemckert

    (Crucell Holland BV)

  • Lennart Holterman

    (Crucell Holland BV)

  • Bing Chen

    (Children's Hospital, Harvard Medical School)

  • Athmanundh Dilraj

    (South African Medical Research Council)

  • Angela Carville

    (New England Primate Research Center)

  • Keith G. Mansfield

    (New England Primate Research Center)

  • Jaap Goudsmit

    (Crucell Holland BV)

  • Dan H. Barouch

    (Beth Israel Deaconess Medical Center, Harvard Medical School)

Abstract

A tailor-made viral vector Adenovirus 5 (Ad5) causes mild respiratory tract infections in humans but its main claim to fame is as a potential vaccine vector for key diseases such as HIV/AIDS and malaria. Its potential clinical utility is, however, hampered by the fact that about half of the population in developed countries and 90% in Africa have been exposed to Ad5 before and have built up immunity. A team based at Harvard Medical School and the Dutch biotechnology company Crucell has devised a way of circumventing this problem by replacing parts of an Ad5 viral capsid protein with those from a related virus, the much rarer Ad48 adenovirus. The strategy was effective in tests in mice and monkeys; if the work can be repeated in humans then modified Ad5 will be a strong candidate as a vector for vaccines and also for delivering gene therapy.

Suggested Citation

  • Diane M. Roberts & Anjali Nanda & Menzo J. E. Havenga & Peter Abbink & Diana M. Lynch & Bonnie A. Ewald & Jinyan Liu & Anna R. Thorner & Patricia E. Swanson & Darci A. Gorgone & Michelle A. Lifton & A, 2006. "Hexon-chimaeric adenovirus serotype 5 vectors circumvent pre-existing anti-vector immunity," Nature, Nature, vol. 441(7090), pages 239-243, May.
    • Handle: RePEc:nat:nature:v:441:y:2006:i:7090:d:10.1038_nature04721
    DOI: 10.1038/nature04721
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