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A small-molecule screen in C. elegans yields a new calcium channel antagonist

Author

Listed:
  • Trevor C. Y. Kwok

    (University of Toronto)

  • Nicole Ricker

    (University of Toronto)

  • Regina Fraser

    (University of Toronto)

  • Allen W. Chan

    (University of Toronto)

  • Andrew Burns

    (University of Toronto)

  • Elise F. Stanley

    (University of Toronto)

  • Peter McCourt

    (University of Toronto
    University of Toronto)

  • Sean R. Cutler

    (University of Toronto)

  • Peter J. Roy

    (University of Toronto
    University of Toronto)

Abstract

C. elegans passes screen test A screen for new small-molecules that induce defects in the nematode C. elegans has led to the discovery of a novel 1,4-dihydropyridine (DHP), called nemadipine-A. DHPs antagonize L-type calcium channels and some are used as drugs to treat hypertension, angina, migraine and heart failure. These results suggest the C. elegans model can play an important role in work on drug discovery and analysis.

Suggested Citation

  • Trevor C. Y. Kwok & Nicole Ricker & Regina Fraser & Allen W. Chan & Andrew Burns & Elise F. Stanley & Peter McCourt & Sean R. Cutler & Peter J. Roy, 2006. "A small-molecule screen in C. elegans yields a new calcium channel antagonist," Nature, Nature, vol. 441(7089), pages 91-95, May.
    • Handle: RePEc:nat:nature:v:441:y:2006:i:7089:d:10.1038_nature04657
    DOI: 10.1038/nature04657
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