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The DNA sequence, annotation and analysis of human chromosome 3

Author

Listed:
  • Donna M. Muzny

    (Baylor College of Medicine)

  • Steven E. Scherer

    (Baylor College of Medicine)

  • Rajinder Kaul

    (University of Washington Genome Center)

  • Jing Wang

    (Chinese Academy of Sciences
    Zhejiang University
    Chinese National Human Genome Center, Beijing (CHGB))

  • Jun Yu

    (Chinese Academy of Sciences
    Zhejiang University
    Chinese National Human Genome Center, Beijing (CHGB))

  • Ralf Sudbrak

    (Max Planck Institute for Molecular Genetics
    Christian-Albrechts University)

  • Christian J. Buhay

    (Baylor College of Medicine)

  • Rui Chen

    (Baylor College of Medicine)

  • Andrew Cree

    (Baylor College of Medicine)

  • Yan Ding

    (Baylor College of Medicine)

  • Shannon Dugan-Rocha

    (Baylor College of Medicine)

  • Rachel Gill

    (Baylor College of Medicine)

  • Preethi Gunaratne

    (Baylor College of Medicine)

  • R. Alan Harris

    (Baylor College of Medicine)

  • Alicia C. Hawes

    (Baylor College of Medicine)

  • Judith Hernandez

    (Baylor College of Medicine)

  • Anne V. Hodgson

    (Baylor College of Medicine)

  • Jennifer Hume

    (Baylor College of Medicine)

  • Andrew Jackson

    (Baylor College of Medicine)

  • Ziad Mohid Khan

    (Baylor College of Medicine)

  • Christie Kovar-Smith

    (Baylor College of Medicine)

  • Lora R. Lewis

    (Baylor College of Medicine)

  • Ryan J. Lozado

    (Baylor College of Medicine)

  • Michael L. Metzker

    (Baylor College of Medicine)

  • Aleksandar Milosavljevic

    (Baylor College of Medicine)

  • George R. Miner

    (Baylor College of Medicine)

  • Margaret B. Morgan

    (Baylor College of Medicine)

  • Lynne V. Nazareth

    (Baylor College of Medicine)

  • Graham Scott

    (Baylor College of Medicine)

  • Erica Sodergren

    (Baylor College of Medicine)

  • Xing-Zhi Song

    (Baylor College of Medicine)

  • David Steffen

    (Baylor College of Medicine)

  • Sharon Wei

    (Baylor College of Medicine)

  • David A. Wheeler

    (Baylor College of Medicine)

  • Mathew W. Wright

    (University College London)

  • Kim C. Worley

    (Baylor College of Medicine)

  • Ye Yuan

    (Baylor College of Medicine)

  • Zhengdong Zhang

    (Baylor College of Medicine)

  • Charles Q. Adams

    (Baylor College of Medicine)

  • M. Ali Ansari-Lari

    (Baylor College of Medicine)

  • Mulu Ayele

    (Baylor College of Medicine)

  • Mary J. Brown

    (Baylor College of Medicine)

  • Guan Chen

    (Baylor College of Medicine)

  • Zhijian Chen

    (Baylor College of Medicine)

  • James Clendenning

    (University of Washington Genome Center)

  • Kerstin P. Clerc-Blankenburg

    (Baylor College of Medicine)

  • Runsheng Chen

    (Chinese Academy of Sciences
    Zhejiang University
    Chinese National Human Genome Center, Beijing (CHGB))

  • Zhu Chen

    (Chinese Academy of Sciences
    Zhejiang University
    Chinese National Human Genome Center, Beijing (CHGB))

  • Clay Davis

    (Baylor College of Medicine)

  • Oliver Delgado

    (Baylor College of Medicine)

  • Huyen H. Dinh

    (Baylor College of Medicine)

  • Wei Dong

    (Chinese Academy of Sciences
    Zhejiang University
    Chinese National Human Genome Center, Beijing (CHGB))

  • Heather Draper

    (Baylor College of Medicine)

  • Stephen Ernst

    (University of Washington Genome Center)

  • Gang Fu

    (Chinese Academy of Sciences
    Zhejiang University
    Chinese National Human Genome Center, Beijing (CHGB))

  • Manuel L. Gonzalez-Garay

    (Baylor College of Medicine)

  • Dawn K. Garcia

    (University of Texas Health Science Center at San Antonio)

  • Will Gillett

    (University of Washington Genome Center)

  • Jun Gu

    (Chinese Academy of Sciences
    Zhejiang University
    Chinese National Human Genome Center, Beijing (CHGB))

  • Bailin Hao

    (Chinese Academy of Sciences
    Zhejiang University
    Chinese National Human Genome Center, Beijing (CHGB))

  • Eric Haugen

    (University of Washington Genome Center)

  • Paul Havlak

    (Baylor College of Medicine)

  • Xin He

    (University of Texas Health Science Center at San Antonio)

  • Steffen Hennig

    (RZPD German Resource Center for Genome Research)

  • Songnian Hu

    (Chinese Academy of Sciences
    Zhejiang University
    Chinese National Human Genome Center, Beijing (CHGB))

  • Wei Huang

    (Chinese Academy of Sciences
    Zhejiang University
    Chinese National Human Genome Center, Beijing (CHGB))

  • Laronda R. Jackson

    (Baylor College of Medicine)

  • Leni S. Jacob

    (Baylor College of Medicine)

  • Susan H. Kelly

    (Baylor College of Medicine)

  • Michael Kube

    (Max Planck Institute for Molecular Genetics)

  • Ruth Levy

    (University of Washington Genome Center)

  • Zhangwan Li

    (Baylor College of Medicine)

  • Bin Liu

    (Chinese Academy of Sciences
    Zhejiang University
    Chinese National Human Genome Center, Beijing (CHGB))

  • Jing Liu

    (Baylor College of Medicine)

  • Wen Liu

    (Baylor College of Medicine)

  • Jing Lu

    (Baylor College of Medicine)

  • Manjula Maheshwari

    (Baylor College of Medicine)

  • Bao-Viet Nguyen

    (Baylor College of Medicine)

  • Geoffrey O. Okwuonu

    (Baylor College of Medicine)

  • Anthony Palmeiri

    (University of Washington Genome Center)

  • Shiran Pasternak

    (Baylor College of Medicine)

  • Lesette M. Perez

    (Baylor College of Medicine)

  • Karen A. Phelps

    (University of Washington Genome Center)

  • Farah J. H. Plopper

    (Baylor College of Medicine)

  • Boqin Qiang

    (Chinese Academy of Sciences
    Zhejiang University
    Chinese National Human Genome Center, Beijing (CHGB))

  • Christopher Raymond

    (University of Washington Genome Center)

  • Ruben Rodriguez

    (University of Texas Health Science Center at San Antonio)

  • Channakhone Saenphimmachak

    (University of Washington Genome Center)

  • Jireh Santibanez

    (Baylor College of Medicine)

  • Hua Shen

    (Baylor College of Medicine)

  • Yan Shen

    (Chinese Academy of Sciences
    Zhejiang University
    Chinese National Human Genome Center, Beijing (CHGB))

  • Sandhya Subramanian

    (University of Washington Genome Center)

  • Paul E. Tabor

    (Baylor College of Medicine)

  • Daniel Verduzco

    (Baylor College of Medicine)

  • Lenee Waldron

    (Baylor College of Medicine)

  • Jian Wang

    (Chinese Academy of Sciences
    Zhejiang University
    Chinese National Human Genome Center, Beijing (CHGB))

  • Jun Wang

    (Chinese Academy of Sciences
    Zhejiang University
    Chinese National Human Genome Center, Beijing (CHGB))

  • Qiaoyan Wang

    (Baylor College of Medicine)

  • Gabrielle A. Williams

    (Baylor College of Medicine)

  • Gane K.-S. Wong

    (Chinese Academy of Sciences
    Zhejiang University
    Chinese National Human Genome Center, Beijing (CHGB))

  • Zhijian Yao

    (Chinese Academy of Sciences
    Zhejiang University
    Chinese National Human Genome Center, Beijing (CHGB))

  • JingKun Zhang

    (Baylor College of Medicine)

  • Xiuqing Zhang

    (Chinese Academy of Sciences
    Zhejiang University
    Chinese National Human Genome Center, Beijing (CHGB))

  • Guoping Zhao

    (Chinese Academy of Sciences
    Zhejiang University
    Chinese National Human Genome Center, Beijing (CHGB))

  • Jianling Zhou

    (Baylor College of Medicine)

  • Yang Zhou

    (University of Washington Genome Center)

  • further contributors
  • David Nelson

    (Baylor College of Medicine)

  • Hans Lehrach

    (Max Planck Institute for Molecular Genetics)

  • Richard Reinhardt

    (Max Planck Institute for Molecular Genetics)

  • Susan L. Naylor

    (University of Texas Health Science Center at San Antonio)

  • Huanming Yang

    (Chinese Academy of Sciences
    Zhejiang University
    Chinese National Human Genome Center, Beijing (CHGB))

  • Maynard Olson

    (University of Washington Genome Center)

  • George Weinstock

    (Baylor College of Medicine)

  • Richard A. Gibbs

    (Baylor College of Medicine)

Abstract

After the completion of a draft human genome sequence1, the International Human Genome Sequencing Consortium has proceeded to finish2 and annotate each of the 24 chromosomes comprising the human genome. Here we describe the sequencing and analysis of human chromosome 3, one of the largest human chromosomes. Chromosome 3 comprises just four contigs, one of which currently represents the longest unbroken stretch of finished DNA sequence known so far. The chromosome is remarkable in having the lowest rate of segmental duplication in the genome. It also includes a chemokine receptor gene cluster as well as numerous loci involved in multiple human cancers such as the gene encoding FHIT, which contains the most common constitutive fragile site in the genome, FRA3B3. Using genomic sequence from chimpanzee and rhesus macaque, we were able to characterize the breakpoints defining a large pericentric inversion that occurred some time after the split of Homininae from Ponginae, and propose an evolutionary history of the inversion.

Suggested Citation

  • Donna M. Muzny & Steven E. Scherer & Rajinder Kaul & Jing Wang & Jun Yu & Ralf Sudbrak & Christian J. Buhay & Rui Chen & Andrew Cree & Yan Ding & Shannon Dugan-Rocha & Rachel Gill & Preethi Gunaratne , 2006. "The DNA sequence, annotation and analysis of human chromosome 3," Nature, Nature, vol. 440(7088), pages 1194-1198, April.
    • Handle: RePEc:nat:nature:v:440:y:2006:i:7088:d:10.1038_nature04728
    DOI: 10.1038/nature04728
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