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Pluripotency of spermatogonial stem cells from adult mouse testis

Author

Listed:
  • Kaomei Guan

    (Georg-August-University of Göttingen)

  • Karim Nayernia

    (Institute of Human Genetics)

  • Lars S. Maier

    (Georg-August-University of Göttingen)

  • Stefan Wagner

    (Georg-August-University of Göttingen)

  • Ralf Dressel

    (Georg-August-University of Göttingen)

  • Jae Ho Lee

    (Institute of Human Genetics)

  • Jessica Nolte

    (Institute of Human Genetics)

  • Frieder Wolf

    (Georg-August-University of Göttingen)

  • Manyu Li

    (Institute of Human Genetics)

  • Wolfgang Engel

    (Institute of Human Genetics)

  • Gerd Hasenfuss

    (Georg-August-University of Göttingen)

Abstract

Match practice Some cells in newborn mouse testis are — like embryonic stem cells — able to generate many different tissue types. Guan et al. have discovered that these cells persist in the adult. Sperm-producing stem cells from mouse adult testis can grow as heart, nerve or muscle cells in the right conditions. If similar multipotent adult germline stem cells (maGSCs) can be isolated from humans — perhaps by simple testicular biopsy — they might provide an alternative source of genetically matched therapeutic cells.

Suggested Citation

  • Kaomei Guan & Karim Nayernia & Lars S. Maier & Stefan Wagner & Ralf Dressel & Jae Ho Lee & Jessica Nolte & Frieder Wolf & Manyu Li & Wolfgang Engel & Gerd Hasenfuss, 2006. "Pluripotency of spermatogonial stem cells from adult mouse testis," Nature, Nature, vol. 440(7088), pages 1199-1203, April.
    • Handle: RePEc:nat:nature:v:440:y:2006:i:7088:d:10.1038_nature04697
    DOI: 10.1038/nature04697
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