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Enhanced bacterial clearance and sepsis resistance in caspase-12-deficient mice

Author

Listed:
  • Maya Saleh

    (La Jolla Institute for Allergy and Immunology
    McGill University)

  • John C. Mathison

    (The Scripps Research Institute)

  • Melissa K. Wolinski

    (La Jolla Institute for Allergy and Immunology)

  • Steve J. Bensinger

    (La Jolla Institute for Allergy and Immunology)

  • Patrick Fitzgerald

    (La Jolla Institute for Allergy and Immunology)

  • Nathalie Droin

    (La Jolla Institute for Allergy and Immunology)

  • Richard J. Ulevitch

    (The Scripps Research Institute)

  • Douglas R. Green

    (La Jolla Institute for Allergy and Immunology
    McGill University
    St Jude Children's Research Hospital)

  • Donald W. Nicholson

    (Merck Research Laboratories)

Abstract

Sepsis target Proteases of the caspase family not only help cells to die (by apoptosis) but also process inflammatory cytokines. Caspase-12 has now been found to inhibit caspase-1, diminishing the production of pro-inflammatory cytokines. Mice lacking caspase-12 are therefore better able to combat bacteria than normal mice and become resistant to peritonitis and septic shock. This makes caspase-12 a potential drug target in the treatment of sepsis.

Suggested Citation

  • Maya Saleh & John C. Mathison & Melissa K. Wolinski & Steve J. Bensinger & Patrick Fitzgerald & Nathalie Droin & Richard J. Ulevitch & Douglas R. Green & Donald W. Nicholson, 2006. "Enhanced bacterial clearance and sepsis resistance in caspase-12-deficient mice," Nature, Nature, vol. 440(7087), pages 1064-1068, April.
    • Handle: RePEc:nat:nature:v:440:y:2006:i:7087:d:10.1038_nature04656
    DOI: 10.1038/nature04656
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