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Proton-coupled electron transfer drives the proton pump of cytochrome c oxidase

Author

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  • Ilya Belevich

    (University of Helsinki)

  • Michael I. Verkhovsky

    (University of Helsinki)

  • Mårten Wikström

    (University of Helsinki)

Abstract

Examining cytochrome c oxidase action shows that electron transfer from the haem group to the oxygen reduction site initiates the proton pumping mechanism — this occurs before relaxation steps, where protons are taken up from the aqueous space on one side of the membrane and released on the other.

Suggested Citation

  • Ilya Belevich & Michael I. Verkhovsky & Mårten Wikström, 2006. "Proton-coupled electron transfer drives the proton pump of cytochrome c oxidase," Nature, Nature, vol. 440(7085), pages 829-832, April.
    • Handle: RePEc:nat:nature:v:440:y:2006:i:7085:d:10.1038_nature04619
    DOI: 10.1038/nature04619
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