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Analysis of the DNA sequence and duplication history of human chromosome 15

Author

Listed:
  • Michael C. Zody

    (Broad Institute of MIT and Harvard)

  • Manuel Garber

    (Broad Institute of MIT and Harvard)

  • Ted Sharpe

    (Broad Institute of MIT and Harvard)

  • Sarah K. Young

    (Broad Institute of MIT and Harvard)

  • Lee Rowen

    (Institute for Systems Biology)

  • Keith O'Neill

    (Broad Institute of MIT and Harvard)

  • Charles A. Whittaker

    (Broad Institute of MIT and Harvard
    MIT Center for Cancer Research)

  • Michael Kamal

    (Broad Institute of MIT and Harvard)

  • Jean L. Chang

    (Broad Institute of MIT and Harvard)

  • Christina A. Cuomo

    (Broad Institute of MIT and Harvard)

  • Ken Dewar

    (Broad Institute of MIT and Harvard
    McGill University and Genome Quebec Innovation Centre)

  • Michael G. FitzGerald

    (Broad Institute of MIT and Harvard)

  • Chinnappa D. Kodira

    (Broad Institute of MIT and Harvard)

  • Anup Madan

    (Institute for Systems Biology
    University of Iowa)

  • Shizhen Qin

    (Institute for Systems Biology)

  • Xiaoping Yang

    (Broad Institute of MIT and Harvard)

  • Nissa Abbasi

    (Institute for Systems Biology
    Fred Hutchinson Cancer Research Center)

  • Amr Abouelleil

    (Broad Institute of MIT and Harvard)

  • Harindra M. Arachchi

    (Broad Institute of MIT and Harvard)

  • Lida Baradarani

    (Institute for Systems Biology
    Blue Heron Technologies)

  • Brian Birditt

    (Institute for Systems Biology
    University of Washington)

  • Scott Bloom

    (Institute for Systems Biology)

  • Toby Bloom

    (Broad Institute of MIT and Harvard)

  • Mark L. Borowsky

    (Broad Institute of MIT and Harvard)

  • Jeremy Burke

    (Institute for Systems Biology)

  • Jonathan Butler

    (Broad Institute of MIT and Harvard)

  • April Cook

    (Broad Institute of MIT and Harvard)

  • Kurt DeArellano

    (Broad Institute of MIT and Harvard)

  • David DeCaprio

    (Broad Institute of MIT and Harvard)

  • Lester Dorris

    (Broad Institute of MIT and Harvard)

  • Monica Dors

    (Institute for Systems Biology)

  • Evan E. Eichler

    (University of Washington)

  • Reinhard Engels

    (Broad Institute of MIT and Harvard)

  • Jessica Fahey

    (Institute for Systems Biology
    Seattle University School of Nursing)

  • Peter Fleetwood

    (Institute for Systems Biology
    Corbis Corporation)

  • Cynthia Friedman

    (Fred Hutchinson Cancer Research Center)

  • Gary Gearin

    (Broad Institute of MIT and Harvard)

  • Jennifer L. Hall

    (Broad Institute of MIT and Harvard)

  • Grace Hensley

    (Institute for Systems Biology
    Geospiza)

  • Ericka Johnson

    (Institute for Systems Biology
    University of Washington)

  • Charlien Jones

    (Broad Institute of MIT and Harvard)

  • Asha Kamat

    (Broad Institute of MIT and Harvard)

  • Amardeep Kaur

    (Institute for Systems Biology)

  • Devin P. Locke

    (University of Washington)

  • Anuradha Madan

    (Institute for Systems Biology
    University of Iowa)

  • Glen Munson

    (Broad Institute of MIT and Harvard)

  • David B. Jaffe

    (Broad Institute of MIT and Harvard)

  • Annie Lui

    (Broad Institute of MIT and Harvard)

  • Pendexter Macdonald

    (Broad Institute of MIT and Harvard)

  • Evan Mauceli

    (Broad Institute of MIT and Harvard)

  • Jerome W. Naylor

    (Broad Institute of MIT and Harvard)

  • Ryan Nesbitt

    (Institute for Systems Biology)

  • Robert Nicol

    (Broad Institute of MIT and Harvard)

  • Sinéad B. O'Leary

    (Broad Institute of MIT and Harvard)

  • Amber Ratcliffe

    (Institute for Systems Biology
    Nanostring Technologies)

  • Steven Rounsley

    (Broad Institute of MIT and Harvard)

  • Xinwei She

    (University of Washington)

  • Katherine M. B. Sneddon

    (University College London)

  • Sandra Stewart

    (Institute for Systems Biology)

  • Carrie Sougnez

    (Broad Institute of MIT and Harvard)

  • Sabrina M. Stone

    (Broad Institute of MIT and Harvard)

  • Kerri Topham

    (Broad Institute of MIT and Harvard)

  • Dascena Vincent

    (Institute for Systems Biology
    Genelex Corporation)

  • Shunguang Wang

    (Broad Institute of MIT and Harvard)

  • Andrew R. Zimmer

    (Broad Institute of MIT and Harvard)

  • Bruce W. Birren

    (Broad Institute of MIT and Harvard)

  • Leroy Hood

    (Institute for Systems Biology)

  • Eric S. Lander

    (Broad Institute of MIT and Harvard)

  • Chad Nusbaum

    (Broad Institute of MIT and Harvard)

Abstract

First fifteen Analysis of human chromosome 15 shows it to be highly segmentally duplicated. The duplications are unusual in that they are clustered in two distinct regions, rather than distributed all along the chromosome. Recombination within the duplications at one of these regions can give rise to deletions that cause Prader–Willi and Angelman syndromes.

Suggested Citation

  • Michael C. Zody & Manuel Garber & Ted Sharpe & Sarah K. Young & Lee Rowen & Keith O'Neill & Charles A. Whittaker & Michael Kamal & Jean L. Chang & Christina A. Cuomo & Ken Dewar & Michael G. FitzGeral, 2006. "Analysis of the DNA sequence and duplication history of human chromosome 15," Nature, Nature, vol. 440(7084), pages 671-675, March.
    • Handle: RePEc:nat:nature:v:440:y:2006:i:7084:d:10.1038_nature04601
    DOI: 10.1038/nature04601
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