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Oncogenic activity of Cdc6 through repression of the INK4/ARF locus

Author

Listed:
  • Susana Gonzalez

    (Tumor Suppression Group)

  • Peter Klatt

    (Tumor Suppression Group)

  • Sonia Delgado

    (CSIC/Universidad de Salamanca)

  • Esther Conde

    (Lung Cancer Group)

  • Fernando Lopez-Rios

    (Hospital Universitario “12 de Octubre”)

  • Montserrat Sanchez-Cespedes

    (Lung Cancer Group)

  • Juan Mendez

    (Spanish National Cancer Research Center (CNIO))

  • Francisco Antequera

    (CSIC/Universidad de Salamanca)

  • Manuel Serrano

    (Tumor Suppression Group)

Abstract

Cancer target The INK4/ARF locus encodes three tumour suppressors and is frequently inactivated in human cancer. Gonzalez et al. have now identified a possible DNA replication origin at the INK4/ARF locus that can mediate its transcriptional silencing, for example when the replication protein Cdc6 is overexpressed as seen in some human tumours. This points to Cdc6 as an alternative target for the inactivation of INK4/ARF in human cancer.

Suggested Citation

  • Susana Gonzalez & Peter Klatt & Sonia Delgado & Esther Conde & Fernando Lopez-Rios & Montserrat Sanchez-Cespedes & Juan Mendez & Francisco Antequera & Manuel Serrano, 2006. "Oncogenic activity of Cdc6 through repression of the INK4/ARF locus," Nature, Nature, vol. 440(7084), pages 702-706, March.
    • Handle: RePEc:nat:nature:v:440:y:2006:i:7084:d:10.1038_nature04585
    DOI: 10.1038/nature04585
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