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Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation

Author

Listed:
  • Mitsuhiro Watanabe

    (CNRS/INSERM/ULP)

  • Sander M. Houten

    (CNRS/INSERM/ULP)

  • Chikage Mataki

    (CNRS/INSERM/ULP)

  • Marcelo A. Christoffolete

    (Brigham and Women's Hospital and Harvard Medical School)

  • Brian W. Kim

    (Brigham and Women's Hospital and Harvard Medical School)

  • Hiroyuki Sato

    (CNRS/INSERM/ULP)

  • Nadia Messaddeq

    (CNRS/INSERM/ULP)

  • John W. Harney

    (Brigham and Women's Hospital and Harvard Medical School)

  • Osamu Ezaki

    (Division of Clinical Nutrition, National Institute of Health and Nutrition)

  • Tatsuhiko Kodama

    (RCAST, University of Tokyo)

  • Kristina Schoonjans

    (CNRS/INSERM/ULP)

  • Antonio C. Bianco

    (Brigham and Women's Hospital and Harvard Medical School)

  • Johan Auwerx

    (CNRS/INSERM/ULP
    Institut Clinique de la Souris)

Abstract

Turn up the heat Bile acids are known to mediate dietary lipid absorption and cholesterol catabolism, and recently an important signalling role emerged. Now they have been found to increase energy expenditure in brown adipose tissue and human skeletal muscle. As bile acid signalling may drive diet-induced heat production, it is a possible therapeutic target for the control of energy homeostasis.

Suggested Citation

  • Mitsuhiro Watanabe & Sander M. Houten & Chikage Mataki & Marcelo A. Christoffolete & Brian W. Kim & Hiroyuki Sato & Nadia Messaddeq & John W. Harney & Osamu Ezaki & Tatsuhiko Kodama & Kristina Schoonj, 2006. "Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation," Nature, Nature, vol. 439(7075), pages 484-489, January.
    • Handle: RePEc:nat:nature:v:439:y:2006:i:7075:d:10.1038_nature04330
    DOI: 10.1038/nature04330
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    Cited by:

    1. Carla Reale & Filomena Russo & Sara Carmela Credendino & Danila Cuomo & Gabriella De Vita & Massimo Mallardo & Francesca Pennino & Immacolata Porreca & Maria Triassi & Mario De Felice & Concetta Ambro, 2019. "A Toxicogenomic Approach Reveals a Novel Gene Regulatory Network Active in In Vitro and In Vivo Models of Thyroid Carcinogenesis," IJERPH, MDPI, vol. 16(1), pages 1-17, January.
    2. Takashi Sasaki & Moeko Mita & Naho Ikari & Ayane Kuboyama & Shuzo Hashimoto & Tatsuya Kaneko & Masaji Ishiguro & Makoto Shimizu & Jun Inoue & Ryuichiro Sato, 2017. "Identification of key amino acid residues in the hTGR5–nomilin interaction and construction of its binding model," PLOS ONE, Public Library of Science, vol. 12(6), pages 1-15, June.

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