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Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6

Author

Listed:
  • Hans Häcker

    (School of Medicine
    St Jude Children's Research Hospital)

  • Vanessa Redecke

    (Department of Medicine)

  • Blagoy Blagoev

    (University of Southern Denmark)

  • Irina Kratchmarova

    (University of Southern Denmark)

  • Li-Chung Hsu

    (School of Medicine)

  • Gang G. Wang

    (University of California)

  • Mark P. Kamps

    (University of California)

  • Eyal Raz

    (Department of Medicine)

  • Hermann Wagner

    (Technische Universität München)

  • Georg Häcker

    (Technische Universität München)

  • Matthias Mann

    (University of Southern Denmark)

  • Michael Karin

    (School of Medicine)

Abstract

Viral response The innate immune response, a vital defence against viral infections, is initiated when viral products induce type I interferon responses via the activation of Toll-like receptors and various cytoplasmic receptors. Two groups this week report on the properties of a molecule called TRAF3. Its function in immune cells was not previously known, but it is now shown to act as a convergence point for induction of the antiviral response by multiple viral recognition pathways.

Suggested Citation

  • Hans Häcker & Vanessa Redecke & Blagoy Blagoev & Irina Kratchmarova & Li-Chung Hsu & Gang G. Wang & Mark P. Kamps & Eyal Raz & Hermann Wagner & Georg Häcker & Matthias Mann & Michael Karin, 2006. "Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6," Nature, Nature, vol. 439(7073), pages 204-207, January.
    • Handle: RePEc:nat:nature:v:439:y:2006:i:7073:d:10.1038_nature04369
    DOI: 10.1038/nature04369
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