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Potentiation of neuroblastoma metastasis by loss of caspase-8

Author

Listed:
  • Dwayne G. Stupack

    (The University of California at San Diego)

  • Tal Teitz

    (Department of Genetics and Tumor Cell Biology)

  • Matthew D. Potter

    (The University of California at San Diego)

  • David Mikolon

    (The University of California at San Diego)

  • Peter J. Houghton

    (St Jude Children's Research Hospital)

  • Vincent J. Kidd

    (Department of Genetics and Tumor Cell Biology)

  • Jill M. Lahti

    (Department of Genetics and Tumor Cell Biology)

  • David A. Cheresh

    (The University of California at San Diego)

Abstract

Caspase 8 in tumours Genetic alterations are common in aggressive neuroblastomas, the most common form of solid tumour in children. In particular the deletion or suppression of the apoptotic protease caspase 8 is common in malignant, disseminated disease. Experiments in neuroblastoma cell lines reveal that caspase 8 has no effect on primary tumour formation; rather it prevents subsequent tissue invasion and metastasis. Acting as a metastasis suppressor by promoting cell death at tumour margins, it prevents the spread of invasive neuroblastoma cells.

Suggested Citation

  • Dwayne G. Stupack & Tal Teitz & Matthew D. Potter & David Mikolon & Peter J. Houghton & Vincent J. Kidd & Jill M. Lahti & David A. Cheresh, 2006. "Potentiation of neuroblastoma metastasis by loss of caspase-8," Nature, Nature, vol. 439(7072), pages 95-99, January.
    • Handle: RePEc:nat:nature:v:439:y:2006:i:7072:d:10.1038_nature04323
    DOI: 10.1038/nature04323
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