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An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection

Author

Listed:
  • Deborah Palliser

    (CBR Institute for Biomedical Research
    Department of Pediatrics)

  • Dipanjan Chowdhury

    (CBR Institute for Biomedical Research
    Department of Pediatrics)

  • Qing-Yin Wang

    (Department of Microbiology and Molecular Genetics)

  • Sandra J. Lee

    (Dana Farber Cancer Institute)

  • Roderick T. Bronson

    (Harvard Medical School)

  • David M. Knipe

    (Department of Microbiology and Molecular Genetics)

  • Judy Lieberman

    (CBR Institute for Biomedical Research
    Department of Pediatrics)

Abstract

RNAi as therapy Gene silencing by small interfering RNAs (siRNAs) is involved in many biological processes. It has the potential to become an important form of therapy, but a major obstacle is the difficulty of delivering siRNA into cells. Palliser et al. now report the efficient delivery of siRNAs in the vagina of mice to protect them from lethal genital herpes simplex virus 2 infection. The development of a microbicide to prevent transmission of sexually transmitted diseases is a high priority for curbing the spread of HIV/AIDS, and herpes simplex virus 2 infection is a cofactor for HIV transmission. This study suggests that it may be possible to use siRNAs as the active component of a vaginal microbicide either prophylactically or to treat sexually transmitted viruses.

Suggested Citation

  • Deborah Palliser & Dipanjan Chowdhury & Qing-Yin Wang & Sandra J. Lee & Roderick T. Bronson & David M. Knipe & Judy Lieberman, 2006. "An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection," Nature, Nature, vol. 439(7072), pages 89-94, January.
    • Handle: RePEc:nat:nature:v:439:y:2006:i:7072:d:10.1038_nature04263
    DOI: 10.1038/nature04263
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