IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v438y2005i7071d10.1038_nature04341.html
   My bibliography  Save this article

Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae

Author

Listed:
  • James E. Galagan

    (The Broad Institute of MIT and Harvard)

  • Sarah E. Calvo

    (The Broad Institute of MIT and Harvard)

  • Christina Cuomo

    (The Broad Institute of MIT and Harvard)

  • Li-Jun Ma

    (The Broad Institute of MIT and Harvard)

  • Jennifer R. Wortman

    (The Institute for Genomic Research)

  • Serafim Batzoglou

    (Stanford University)

  • Su-In Lee

    (Stanford University)

  • Meray Baştürkmen

    (Oregon Health & Science University
    Science University)

  • Christina C. Spevak

    (Oregon Health & Science University
    Science University)

  • John Clutterbuck

    (University of Glasgow)

  • Vladimir Kapitonov

    (Genetic Information Research Institute)

  • Jerzy Jurka

    (Genetic Information Research Institute)

  • Claudio Scazzocchio

    (Université Paris-Sud, UMR8621)

  • Mark Farman

    (Plant Science Building, 1405 Veteran's Drive, University of Kentucky)

  • Jonathan Butler

    (The Broad Institute of MIT and Harvard)

  • Seth Purcell

    (The Broad Institute of MIT and Harvard)

  • Steve Harris

    (University of Nebraska)

  • Gerhard H. Braus

    (Georg-August-University Gottingen)

  • Oliver Draht

    (Georg-August-University Gottingen)

  • Silke Busch

    (Georg-August-University Gottingen)

  • Christophe D'Enfert

    (INRA USC 2019)

  • Christiane Bouchier

    (Génopole-PF1)

  • Gustavo H. Goldman

    (Universidade de Sao Paulo)

  • Deborah Bell-Pedersen

    (Texas A&M University)

  • Sam Griffiths-Jones

    (Wellcome Trust Genome Campus)

  • John H. Doonan

    (John Innes Centre)

  • Jaehyuk Yu

    (The University of Wisconsin-Madison)

  • Kay Vienken

    (Max Planck Institute for terrestrial Microbiology)

  • Arnab Pain

    (Wellcome Trust Genome Campus)

  • Michael Freitag

    (University of Oregon)

  • Eric U. Selker

    (University of Oregon)

  • David B. Archer

    (University Park, University of Nottingham)

  • Miguel Á. Peñalva

    (Consejo Superior de Investigaciones Científicas)

  • Berl R. Oakley

    (The Ohio State University)

  • Michelle Momany

    (The University of Georgia)

  • Toshihiro Tanaka

    (National Institute of Technology and Evaluation (NITE))

  • Toshitaka Kumagai

    (National Institute of Advanced Industrial Science and Technology (AIST))

  • Kiyoshi Asai

    (National Institute of Advanced Industrial Science and Technology (AIST))

  • Masayuki Machida

    (National Institute of Advanced Industrial Science and Technology (AIST))

  • William C. Nierman

    (The Institute for Genomic Research
    The George Washington University School of Medicine)

  • David W. Denning

    (The University of Manchester)

  • Mark Caddick

    (Donnan Labs, The University of Liverpool)

  • Michael Hynes

    (University of Melbourne)

  • Mathieu Paoletti

    (University Park, University of Nottingham)

  • Reinhard Fischer

    (Max Planck Institute for terrestrial Microbiology
    Institute for Applied Biosiences at the University of Karlsruhe)

  • Bruce Miller

    (University of Idaho)

  • Paul Dyer

    (University Park, University of Nottingham)

  • Matthew S. Sachs

    (Oregon Health & Science University
    Science University)

  • Stephen A. Osmani

    (The Ohio State University)

  • Bruce W. Birren

    (The Broad Institute of MIT and Harvard)

Abstract

The aspergilli comprise a diverse group of filamentous fungi spanning over 200 million years of evolution. Here we report the genome sequence of the model organism Aspergillus nidulans, and a comparative study with Aspergillus fumigatus, a serious human pathogen, and Aspergillus oryzae, used in the production of sake, miso and soy sauce. Our analysis of genome structure provided a quantitative evaluation of forces driving long-term eukaryotic genome evolution. It also led to an experimentally validated model of mating-type locus evolution, suggesting the potential for sexual reproduction in A. fumigatus and A. oryzae. Our analysis of sequence conservation revealed over 5,000 non-coding regions actively conserved across all three species. Within these regions, we identified potential functional elements including a previously uncharacterized TPP riboswitch and motifs suggesting regulation in filamentous fungi by Puf family genes. We further obtained comparative and experimental evidence indicating widespread translational regulation by upstream open reading frames. These results enhance our understanding of these widely studied fungi as well as provide new insight into eukaryotic genome evolution and gene regulation.

Suggested Citation

  • James E. Galagan & Sarah E. Calvo & Christina Cuomo & Li-Jun Ma & Jennifer R. Wortman & Serafim Batzoglou & Su-In Lee & Meray Baştürkmen & Christina C. Spevak & John Clutterbuck & Vladimir Kapitonov &, 2005. "Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae," Nature, Nature, vol. 438(7071), pages 1105-1115, December.
    • Handle: RePEc:nat:nature:v:438:y:2005:i:7071:d:10.1038_nature04341
    DOI: 10.1038/nature04341
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature04341
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature04341?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:438:y:2005:i:7071:d:10.1038_nature04341. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.