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Glyoxalase 1 and glutathione reductase 1 regulate anxiety in mice

Author

Listed:
  • Iiris Hovatta

    (Laboratory of Genetics)

  • Richard S. Tennant

    (Laboratory of Genetics)

  • Robert Helton

    (Laboratory of Genetics
    BrainCells Inc.)

  • Robert A. Marr

    (Laboratory of Genetics)

  • Oded Singer

    (Laboratory of Genetics)

  • Jeffrey M. Redwine

    (Neurome Inc.)

  • Julie A. Ellison

    (Laboratory of Genetics)

  • Eric E. Schadt

    (Merck & Co.)

  • Inder M. Verma

    (Laboratory of Genetics)

  • David J. Lockhart

    (Laboratory of Genetics)

  • Carrolee Barlow

    (Laboratory of Genetics
    BrainCells Inc.)

Abstract

The control of anxiety In conditions such as panic disorder, phobias and generalized anxiety disorder, an individual loses control of the fear and anxiety response, an important aid to survival when functioning normally. To learn more about the molecular and genetic basis for the regulation of the anxiety response, Hovatta et al. used a combination of behavioural testing in mice with gene expression profiling. They found two genes linked to anxiety: glyoxalase 1 and glutathione reductase. This establishes an association between anxiety and oxidative stress metabolism, and identifies potential biochemical pathways and molecular candidates for therapeutic intervention in anxiety disorders.

Suggested Citation

  • Iiris Hovatta & Richard S. Tennant & Robert Helton & Robert A. Marr & Oded Singer & Jeffrey M. Redwine & Julie A. Ellison & Eric E. Schadt & Inder M. Verma & David J. Lockhart & Carrolee Barlow, 2005. "Glyoxalase 1 and glutathione reductase 1 regulate anxiety in mice," Nature, Nature, vol. 438(7068), pages 662-666, December.
    • Handle: RePEc:nat:nature:v:438:y:2005:i:7068:d:10.1038_nature04250
    DOI: 10.1038/nature04250
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