IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v438y2005i7066d10.1038_nature04267.html
   My bibliography  Save this article

Control of B-cell responses by Toll-like receptors

Author

Listed:
  • Chandrashekhar Pasare

    (Yale University School of Medicine)

  • Ruslan Medzhitov

    (Yale University School of Medicine)

Abstract

Toll-like receptors (TLRs) detect microbial infection and have an essential role in the induction of immune responses1,2,3. TLRs can directly induce innate host defence responses, but the mechanisms of TLR-mediated control of adaptive immunity are not fully understood. Although TLR-induced dendritic cell maturation is required for activation of T-helper (TH) cells4, the role of TLRs in B-cell activation and antibody production in vivo is not yet known. Here we show that activation and differentiation of TH cells is not sufficient for the induction of T-dependent B-cell responses. We find that, in addition to CD4+ T-cell help, generation of T-dependent antigen-specific antibody responses requires activation of TLRs in B cells.

Suggested Citation

  • Chandrashekhar Pasare & Ruslan Medzhitov, 2005. "Control of B-cell responses by Toll-like receptors," Nature, Nature, vol. 438(7066), pages 364-368, November.
    • Handle: RePEc:nat:nature:v:438:y:2005:i:7066:d:10.1038_nature04267
    DOI: 10.1038/nature04267
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature04267
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature04267?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:438:y:2005:i:7066:d:10.1038_nature04267. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.