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Specification of astrocytes by bHLH protein SCL in a restricted region of the neural tube

Author

Listed:
  • Yuko Muroyama

    (Dana-Farber Cancer Institute
    Graduate School of Medicine, Chiba University)

  • Yuko Fujiwara

    (Howard Hughes Medical Institute and Divisions of Hematology)

  • Stuart H. Orkin

    (Dana-Farber Cancer Institute
    Howard Hughes Medical Institute and Divisions of Hematology)

  • David H. Rowitch

    (Dana-Farber Cancer Institute
    Children's Hospital)

Abstract

Brain cell fates Astrocytes are one of three principal cell types that make up the brain, but surprisingly little is known about how these cells are formed during brain development. Now a protein called SCL, a basic helix–loop–helix transcription factor, is shown to instruct immature neural stem cells to become astrocytes. SCL is the first known protein with this role and understanding its function could provide insight into the contributions of astrocytes in human neurological diseases such as brain cancer, amyotrophic lateral sclerosis and Alzheimer's disease.

Suggested Citation

  • Yuko Muroyama & Yuko Fujiwara & Stuart H. Orkin & David H. Rowitch, 2005. "Specification of astrocytes by bHLH protein SCL in a restricted region of the neural tube," Nature, Nature, vol. 438(7066), pages 360-363, November.
    • Handle: RePEc:nat:nature:v:438:y:2005:i:7066:d:10.1038_nature04139
    DOI: 10.1038/nature04139
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