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Rewiring the adult brain

Author

Listed:
  • Michael B. Calford

    (School of Biomedical Sciences, The University of Newcastle)

  • Yuzo M. Chino

    (College of Optometry, University of Houston)

  • Aniruddha Das

    (Columbia University Medical School)

  • Ulf T. Eysel

    (Faculty of Medicine, Ruhr-University Bochum)

  • Charles D. Gilbert

    (The Rockefeller University)

  • Stephen J. Heinen

    (The Smith-Kettlewell Eye Research Institute)

  • Jon H. Kaas

    (Vanderbilt University)

  • Shimon Ullman

    (Weizmann Institute)

Abstract

Arising from: S. M. Smirnakis et al. Nature 435, 300–307 (2005); S. M. Smirnakis et al. reply Any analysis of plastic reorganization at a neuronal locus needs a veridical measure of changes in the functional output — that is, spiking responses of the neurons in question. In a study of the effect of retinal lesions on adult primary visual cortex (V1), Smirnakis et al.1 propose that there is no cortical reorganization. Their results are based, however, on BOLD (blood-oxygen-level-dependent) fMRI (functional magnetic resonance imaging), which provides an unreliable gauge of spiking activity. We therefore question their criterion for lack of plasticity, particularly in the light of the large body of earlier work that demonstrates cortical plasticity.

Suggested Citation

  • Michael B. Calford & Yuzo M. Chino & Aniruddha Das & Ulf T. Eysel & Charles D. Gilbert & Stephen J. Heinen & Jon H. Kaas & Shimon Ullman, 2005. "Rewiring the adult brain," Nature, Nature, vol. 438(7065), pages 3-3, November.
    • Handle: RePEc:nat:nature:v:438:y:2005:i:7065:d:10.1038_nature04359
    DOI: 10.1038/nature04359
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