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Protection of macaques from vaginal SHIV challenge by vaginally delivered inhibitors of virus–cell fusion

Author

Listed:
  • Ronald S. Veazey

    (Tulane National Primate Research Center)

  • Per Johan Klasse

    (Weill Medical College of Cornell University)

  • Susan M. Schader

    (Weill Medical College of Cornell University)

  • Qinxue Hu

    (University of London)

  • Thomas J. Ketas

    (Weill Medical College of Cornell University)

  • Min Lu

    (Weill Medical College of Cornell University)

  • Preston A. Marx

    (Tulane National Primate Research Center)

  • Jason Dufour

    (Tulane National Primate Research Center)

  • Richard J. Colonno

    (Bristol-Myers Squibb Pharmaceutical Institute)

  • Robin J. Shattock

    (University of London)

  • Martin S. Springer

    (Merck Research Laboratories)

  • John P. Moore

    (Weill Medical College of Cornell University)

Abstract

Anti-HIV microbicide A trial of three inhibitors of HIV-1 entry into target cells, administered vaginally in macaque monkeys prior to intercourse, shows that they can protect against infection by a simian-human immunodeficiency virus. One molecule, the antiviral CMPD 167, is particularly potent, providing protection when applied 6 hours before challenge. The macaque model is a proven test of AIDS prevention strategies, so these findings bode well for the prospects of similar compounds in humans.

Suggested Citation

  • Ronald S. Veazey & Per Johan Klasse & Susan M. Schader & Qinxue Hu & Thomas J. Ketas & Min Lu & Preston A. Marx & Jason Dufour & Richard J. Colonno & Robin J. Shattock & Martin S. Springer & John P. M, 2005. "Protection of macaques from vaginal SHIV challenge by vaginally delivered inhibitors of virus–cell fusion," Nature, Nature, vol. 438(7064), pages 99-102, November.
    • Handle: RePEc:nat:nature:v:438:y:2005:i:7064:d:10.1038_nature04055
    DOI: 10.1038/nature04055
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