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Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation

Author

Listed:
  • Ignacio Varela

    (Instituto Universitario de Oncología
    University of Hong Kong)

  • Juan Cadiñanos

    (Instituto Universitario de Oncología
    University of Hong Kong)

  • Alberto M. Pendás

    (Instituto Universitario de Oncología)

  • Ana Gutiérrez-Fernández

    (Instituto Universitario de Oncología)

  • Alicia R. Folgueras

    (Instituto Universitario de Oncología)

  • Luis M. Sánchez

    (Instituto Universitario de Oncología)

  • Zhongjun Zhou

    (Karolinska Institutet)

  • Francisco J. Rodríguez

    (Instituto Universitario de Oncología)

  • Colin L. Stewart

    (National Cancer Institute)

  • José A Vega

    (Universidad de Oviedo)

  • Karl Tryggvason

    (Karolinska Institutet)

  • José M. P. Freije

    (Instituto Universitario de Oncología)

  • Carlos López-Otín

    (Instituto Universitario de Oncología)

Abstract

Linking p53 and ageing A paper published in Nature in January 2002 caught the attention of those working on both ageing and cancer researcher: mice with a hyperactive p53 tumour suppressor gene were resistant to cancer but, here was the surprise, also showed signs of premature ageing. The link between p53 signalling and ageing is further explored in a study of the molecular mechanisms behind the striking accelerated ageing observed in mutant mice deficient in a metalloprotease called Zmpste24, a condition similar to some premature ageing syndromes in humans. The protease deficiency induces a p53 signalling pathway, accompanied by increased cellular senescence and accelerated ageing at the organismal level.

Suggested Citation

  • Ignacio Varela & Juan Cadiñanos & Alberto M. Pendás & Ana Gutiérrez-Fernández & Alicia R. Folgueras & Luis M. Sánchez & Zhongjun Zhou & Francisco J. Rodríguez & Colin L. Stewart & José A Vega & Karl T, 2005. "Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation," Nature, Nature, vol. 437(7058), pages 564-568, September.
    • Handle: RePEc:nat:nature:v:437:y:2005:i:7058:d:10.1038_nature04019
    DOI: 10.1038/nature04019
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