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DNA sequence and analysis of human chromosome 18

Author

Listed:
  • Chad Nusbaum

    (Broad Institute of MIT and Harvard)

  • Michael C. Zody

    (Broad Institute of MIT and Harvard)

  • Mark L. Borowsky

    (Broad Institute of MIT and Harvard)

  • Michael Kamal

    (Broad Institute of MIT and Harvard)

  • Chinnappa D. Kodira

    (Broad Institute of MIT and Harvard)

  • Todd D. Taylor

    (RIKEN Genomic Sciences Center)

  • Charles A. Whittaker

    (Broad Institute of MIT and Harvard
    MIT Center for Cancer Research)

  • Jean L. Chang

    (Broad Institute of MIT and Harvard)

  • Christina A. Cuomo

    (Broad Institute of MIT and Harvard)

  • Ken Dewar

    (Broad Institute of MIT and Harvard
    McGill University and Genome Quebec Innovation Centre)

  • Michael G. FitzGerald

    (Broad Institute of MIT and Harvard)

  • Xiaoping Yang

    (Broad Institute of MIT and Harvard)

  • Amr Abouelleil

    (Broad Institute of MIT and Harvard)

  • Nicole R. Allen

    (Broad Institute of MIT and Harvard)

  • Scott Anderson

    (Broad Institute of MIT and Harvard)

  • Toby Bloom

    (Broad Institute of MIT and Harvard)

  • Boris Bugalter

    (Broad Institute of MIT and Harvard)

  • Jonathan Butler

    (Broad Institute of MIT and Harvard)

  • April Cook

    (Broad Institute of MIT and Harvard)

  • David DeCaprio

    (Broad Institute of MIT and Harvard)

  • Reinhard Engels

    (Broad Institute of MIT and Harvard)

  • Manuel Garber

    (Broad Institute of MIT and Harvard)

  • Andreas Gnirke

    (Broad Institute of MIT and Harvard)

  • Nabil Hafez

    (Broad Institute of MIT and Harvard)

  • Jennifer L. Hall

    (Broad Institute of MIT and Harvard)

  • Catherine Hosage Norman

    (Broad Institute of MIT and Harvard)

  • Takehiko Itoh

    (Mitsubishi Research Institute Inc.)

  • David B. Jaffe

    (Broad Institute of MIT and Harvard)

  • Yoko Kuroki

    (RIKEN Genomic Sciences Center)

  • Jessica Lehoczky

    (Broad Institute of MIT and Harvard
    University of Michigan Medical School)

  • Annie Lui

    (Broad Institute of MIT and Harvard)

  • Pendexter Macdonald

    (Broad Institute of MIT and Harvard)

  • Evan Mauceli

    (Broad Institute of MIT and Harvard)

  • Tarjei S. Mikkelsen

    (Broad Institute of MIT and Harvard)

  • Jerome W. Naylor

    (Broad Institute of MIT and Harvard)

  • Robert Nicol

    (Broad Institute of MIT and Harvard)

  • Cindy Nguyen

    (Broad Institute of MIT and Harvard)

  • Hideki Noguchi

    (RIKEN Genomic Sciences Center
    University of Tokyo)

  • Sinéad B. O'Leary

    (Broad Institute of MIT and Harvard)

  • Bruno Piqani

    (Broad Institute of MIT and Harvard)

  • Cherylyn L Smith

    (Broad Institute of MIT and Harvard)

  • Jessica A. Talamas

    (Broad Institute of MIT and Harvard)

  • Kerri Topham

    (Broad Institute of MIT and Harvard)

  • Yasushi Totoki

    (RIKEN Genomic Sciences Center)

  • Atsushi Toyoda

    (RIKEN Genomic Sciences Center)

  • Hester M. Wain

    (University College London)

  • Sarah K. Young

    (Broad Institute of MIT and Harvard)

  • Qiandong Zeng

    (Broad Institute of MIT and Harvard)

  • Andrew R. Zimmer

    (Broad Institute of MIT and Harvard)

  • Asao Fujiyama

    (RIKEN Genomic Sciences Center
    National Institute of Informatics)

  • Masahira Hattori

    (RIKEN Genomic Sciences Center
    Kitasato University 1-15-1)

  • Bruce W. Birren

    (Broad Institute of MIT and Harvard)

  • Yoshiyuki Sakaki

    (RIKEN Genomic Sciences Center)

  • Eric S. Lander

    (Broad Institute of MIT and Harvard)

Abstract

Secret Code The sequence of human chromosome 18, which has the lowest gene density of any human chromosome, is now complete. Surprisingly, the proportion of non-protein-coding regions evolutionarily conserved among mammals is close to the genome-wide average. This suggests that there is more to non-coding sequences than meets the eye, and that they are well worth holding on to.

Suggested Citation

  • Chad Nusbaum & Michael C. Zody & Mark L. Borowsky & Michael Kamal & Chinnappa D. Kodira & Todd D. Taylor & Charles A. Whittaker & Jean L. Chang & Christina A. Cuomo & Ken Dewar & Michael G. FitzGerald, 2005. "DNA sequence and analysis of human chromosome 18," Nature, Nature, vol. 437(7058), pages 551-555, September.
    • Handle: RePEc:nat:nature:v:437:y:2005:i:7058:d:10.1038_nature03983
    DOI: 10.1038/nature03983
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