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Hoogsteen base-pairing in DNA replication? (reply)

Author

Listed:
  • Aneel Aggarwal

    (Mount Sinai School of Medicine)

  • Deepak Nair

    (Mount Sinai School of Medicine)

  • Robert Johnson

    (Sealy Center for Molecular Science, University of Texas Medical Branch)

  • Louise Prakash

    (Sealy Center for Molecular Science, University of Texas Medical Branch)

  • Satya Prakash

    (Sealy Center for Molecular Science, University of Texas Medical Branch)

Abstract

We have solved the crystal structure of human DNA polymerase-ι (hPolι) bound to a template primer and incoming nucleotide, and shown that hPolι uses Hoogsteen base-pairing for normal DNA synthesis1. Jimin Wang questions the space group we used and claims that Hoogsteen base-pairing is not supported by our electron-density maps2. We show here that the issue of space group does not affect our conclusions1 and that our electron-density maps are clear in indicating that Hoogsteen and not Watson–Crick base-pairing occurs in this situation.

Suggested Citation

  • Aneel Aggarwal & Deepak Nair & Robert Johnson & Louise Prakash & Satya Prakash, 2005. "Hoogsteen base-pairing in DNA replication? (reply)," Nature, Nature, vol. 437(7057), pages 7-7, September.
    • Handle: RePEc:nat:nature:v:437:y:2005:i:7057:d:10.1038_nature04200
    DOI: 10.1038/nature04200
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